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    Indole-3-acetic acid correlates with monocyte-to-high-density lipoprotein (HDL) ratio (MHR) in chronic kidney disease patients

    Indole-3-acetic acid is a protein-bound indolic uremic toxin deriving from tryptophan metabolism. Increased levels are associated with higher thrombotic risk and both cardiovascular and all-cause mortality. An...

    Valeria Cernaro, Vincenzo Calabrese, Saverio Loddo in International Urology and Nephrology (2022)

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    RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus

    Kynurenine pathway of tryptophan metabolism is involved in the pathophysiology of chronic kidney disease (CKD) and diabetes mellitus, mainly through the inflammation-induced activity of indoleamine 2,3-dioxyge...

    Valeria Cernaro, Saverio Loddo, Vincenzo Macaione in International Urology and Nephrology (2020)

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    Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury

    TBI is the main cause of death and disability in individuals aged 1–45 in Western countries. One of the main challenges of TBI at present is the lack of specific diagnostic biomarkers, especially for mild TBI ...

    Francesca Polito, Fausto Famà, Rosaria Oteri, Giovanni Raffa in Molecular Biology Reports (2020)