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Article
Open AccessIntracortical recordings reveal vision-to-action cortical gradients driving human exogenous attention
Exogenous attention, the process that makes external salient stimuli pop-out of a visual scene, is essential for survival. How attention-capturing events modulate human brain processing remains unclear. Here w...
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Article
Open AccessHuman thalamic low-frequency oscillations correlate with expected value and outcomes during reinforcement learning
Reinforcement-based adaptive decision-making is believed to recruit fronto-striatal circuits. A critical node of the fronto-striatal circuit is the thalamus. However, direct evidence of its involvement in huma...
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Article
Open AccessFronto-parietal networks shape human conscious report through attention gain and reorienting
How do attention and consciousness interact in the human brain? Rival theories of consciousness disagree on the role of fronto-parietal attentional networks in conscious perception. We recorded neural activity...
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Article
Open AccessValproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial
Generalised convulsive status epilepticus (GCSE) is a medical emergency. Guidelines recommend a stepwise strategy of benzodiazepines followed by a second-line anti-seizure medicine (ASM). However, GCSE is unco...
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Article
Clinico-biological markers for the prognosis of status epilepticus in adults
Prediction of mortality, functional outcome and recovery after status epilepticus (SE) is a challenge. Biological and clinical markers have been proposed to reflect the brain injury or to monitor critical ill ...
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Article
Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies
To characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic encephalitis, including factors associated with drug-resistant epilepsy (DRE).
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Article
A review of the natural history of Sturge–Weber syndrome through adulthood
Sturge–Weber syndrome (SWS) is a neurocutaneous disorder caused by a somatic mutation in the GNAQ gene, leading to capillary venous malformations with neurological, ocular, and cutaneous abnormalities. Descriptio...
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Article
Epilepsy related to focal neuronal lipofuscinosis: extra-frontal localization, EEG signatures and GABA involvement
Focal neuronal lipofuscinosis (FNL) is an uncommon epileptic disorder related to an excess of lipofuscin accumulation within dysmorphic-appearing neurons (DANs), whose epileptogenic mechanisms are still poorly...
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Article
Neuron Specific Enolase, S100-beta protein and progranulin as diagnostic biomarkers of status epilepticus
Status epilepticus (SE) is a life-threatening prolonged epileptic seizure. A rapid diagnosis is fundamental to initiate antiepileptic treatment and to prevent the development of neurological sequels. Several s...
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Article
When should we test patients with epilepsy for autoimmune antibodies? Results from a French retrospective single center study
Seizures represent a core symptom of autoimmune encephalitides with specific therapeutic issues. To date, patients with new-onset seizures or established epilepsy are not systematically tested for autoimmune a...
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Article
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures
Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. Mutations of LGI1 have been linked to aut...
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Article
Open AccessA self-supervised learning strategy for postoperative brain cavity segmentation simulating resections
Accurate segmentation of brain resection cavities (RCs) aids in postoperative analysis and determining follow-up treatment. Convolutional neural networks (CNNs) are the state-of-the-art image segmentation tech...
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Article
Familial autoimmunity in neurological patients with GAD65 antibodies: an interview-based study
The common co-occurrence of autoimmune systemic diseases in patients with neurological disorders and antibodies against glutamic acid decarboxylase 65 (GAD65) suggests a shared genetic predisposition to these ...
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Article
Four core properties of the human brain valuation system demonstrated in intracranial signals
Estimating the value of alternative options is a key process in decision-making. Human functional magnetic resonance imaging and monkey electrophysiology studies have identified brain regions, such as the vent...
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Article
Open AccessValue and mechanisms of EEG reactivity in the prognosis of patients with impaired consciousness: a systematic review
Electroencephalography (EEG) is a well-established tool for assessing brain function that is available at the bedside in the intensive care unit (ICU). This review aims to discuss the relevance of electroencep...
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Article
Open AccessAdolescence/adult onset MTHFR deficiency may manifest as isolated and treatable distinct neuro-psychiatric syndromes
5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clini...
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Article
Understanding Lennox–Gastaut syndrome: insights from focal epilepsy patients with Lennox–Gastaut features
To delineate the clinical and EEG features of adults with focal epilepsy associated with a generalized paroxysmal fast activity (GPFA) pattern on EEG who developed refractory seizures, notably drop attacks, bu...
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Article
Medial temporal lobe epilepsy associated with hippocampal sclerosis is a distinctive syndrome
Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal s...
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Article
Open AccessCognitive dissonance resolution depends on episodic memory
The notion that past choices affect preferences is one of the most influential concepts of social psychology since its first report in the 50 s, and its theorization within the cognitive dissonance framework. ...
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Article
Open AccessEfficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial
Generalized tonic-clonic seizures (GTCSs) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Experimental and clinical data strongly suggest that the majority of SUDEP results from a pos...
