73 Result(s)

Article

Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidn...

Peter Pickkers, Derek C. Angus, Kristie Bass, Rinaldo Bellomo… in Intensive Care Medicine (2024)

Article

Non-interventional follow-up versus fluid bolus in RESPONSE to oliguria in hemodynamically stable critically ill patients: a randomized controlled pilot trial

Fluid bolus therapy is a common intervention to improve urine output. Data concerning the effect of a fluid bolus on oliguria originate mainly from observational studies and remain controversial regarding the ...

Nina Inkinen, Ville Pettilä, Miia Valkonen, Maija Serlo, Minna Bäcklund… in Critical Care (2022)

Article

Variation in severity-adjusted resource use and outcome in intensive care units

Intensive care patients have increased risk of death and their care is expensive. We investigated whether risk-adjusted mortality and resources used to achieve survivors change over time and if their variation...

Jukka Takala, André Moser, Rahul Raj, Ville Pettilä… in Intensive Care Medicine (2022)

Article

Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial

We compared a restrictive fluid management strategy to usual care among critically ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation.

Suvi T. Vaara, Marlies Ostermann, Laurent Bitker… in Intensive Care Medicine (2021)

Article

Ensemble machine learning prediction and variable importance analysis of 5-year mortality after cardiac valve and CABG operations

Despite having a similar post-operative complication profile, cardiac valve operations are associated with a higher mortality rate compared to coronary artery bypass grafting (CABG) operations. For long-term m...

José Castela Forte, Hubert E. Mungroop, Fred de Geus… in Scientific Reports (2021)

Article

Serum fibroblast growth factor 21 levels after out of hospital cardiac arrest are associated with neurological outcome

Fibroblast growth factor (FGF) 21 is a marker associated with mitochondrial and cellular stress. Cardiac arrest causes mitochondrial stress, and we tested if FGF 21 would reflect the severity of hypoxia-reperf...

Pirkka T. Pekkarinen, Markus B. Skrifvars, Ville Lievonen… in Scientific Reports (2021)

Article

Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial

Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcom...

Lauri Wihersaari, Nicholas J. Ashton, Matti Reinikainen… in Intensive Care Medicine (2021)

Article

Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung

Juho Jalkanen, Ville Pettilä, Teppo Huttunen, Maija Hollmén… in Intensive Care Medicine (2020)

Article

Urine NGAL as a biomarker for septic AKI: a critical appraisal of clinical utility—data from the observational FINNAKI study

Neutrophil gelatinase-associated lipocalin (NGAL) is released from kidney tubular cells under stress as well as from neutrophils during inflammation. It has been suggested as a biomarker for acute kidney injur...

Sanna Törnblom, Sara Nisula, Liisa Petäjä, Suvi T. Vaara… in Annals of Intensive Care (2020)

Article

Different applications of the KDIGO criteria for AKI lead to different incidences in critically ill patients: a post hoc analysis from the prospective observational SICS-II study

Acute kidney injury (AKI) is a frequent and clinically relevant problem in critically ill patients. Various randomized controlled trials (RCT) have attempted to assess potentially beneficial treatments for AKI...

Renske Wiersema, Sakari Jukarainen, Ruben J. Eck, Thomas Kaufmann… in Critical Care (2020)

Article

Two subphenotypes of septic acute kidney injury are associated with different 90-day mortality and renal recovery

The pathophysiology of septic acute kidney injury is inadequately understood. Recently, subphenotypes for sepsis and AKI have been derived. The objective of this study was to assess whether a combination of co...

Renske Wiersema, Sakari Jukarainen, Suvi T. Vaara, Meri Poukkanen… in Critical Care (2020)

Article

Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort

Acute kidney injury (AKI) is a frequently occurring syndrome in critically ill patients and is associated with worse outcomes. Biomarkers allow early identification and therapy of AKI which may improve outcome...

Eric A. Hoste, Suvi T. Vaara, Jorien De Loor, Mikko Haapio, Lieve Nuytinck… in Critical Care (2020)

Article

Effect and safety of 4% albumin in the treatment of cardiac surgery patients: study protocol for the randomized, double-blind, clinical ALBICS (ALBumin In Cardiac Surgery) trial

In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may r...

Hanna Vlasov, Tatu Juvonen, Seppo Hiippala, Raili Suojaranta, Markku Peltonen… in Trials (2020)

Article

Burden of acute kidney injury and 90-day mortality in critically ill patients

Mortality rates associated with acute kidney injury (AKI) vary among critically ill patients. Outcomes are often not corrected for severity or duration of AKI. Our objective was to analyse whether a new variab...

Renske Wiersema, Ruben J. Eck, Mikko Haapio, Jacqueline Koeze… in BMC Nephrology (2019)

Article

Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Injury to endothelium and glycocalyx predisposes to vascular leak, which may subsequently lead to increased fluid requirements and worse outcomes. In this post hoc study of the prospective multicenter observat...

Nina Inkinen, Ville Pettilä, Päivi Lakkisto, Anne Kuitunen… in Annals of Intensive Care (2019)

Article

The origin of plasma neutrophil gelatinase-associated lipocalin in cardiac surgery

Acute kidney injury (AKI) is common after heart surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is produced in injured kidney. NGAL has been used as an early plasma biomarker for AKI in patients und...

Arie Passov, Liisa Petäjä, Marjut Pihlajoki, Ulla-Stina Salminen… in BMC Nephrology (2019)

Article

Near-infrared spectroscopy after out-of-hospital cardiac arrest

Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...

Pekka Jakkula, Johanna Hästbacka, Matti Reinikainen, Ville Pettilä… in Critical Care (2019)

Article

Associations between tricuspid annular plane systolic excursion to reflect right ventricular function and acute kidney injury in critically ill patients: a SICS-I sub-study

Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations b...

Renske Wiersema, Jacqueline Koeze, Bart Hiemstra, Ville Pettilä… in Annals of Intensive Care (2019)

Article

Focus on randomised clinical trials

Anders Perner, Peter B. Hjortrup, Ville Pettilä in Intensive Care Medicine (2018)