50 Result(s)
within
Ville Pettila
Pain Medicine
-
Article
Open AccessCorrection: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
-
Article
Open AccessPhase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidn...
-
Article
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial
There is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury (AKI).
-
Article
Open AccessVariation in severity-adjusted resource use and outcome in intensive care units
Intensive care patients have increased risk of death and their care is expensive. We investigated whether risk-adjusted mortality and resources used to achieve survivors change over time and if their variation...
-
Article
Open AccessRestrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial
We compared a restrictive fluid management strategy to usual care among critically ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation.
-
Article
Open AccessNeurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial
Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcom...
-
Article
Open AccessGlucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung
-
Article
NSE concentrations and haemolysis after cardiac arrest
-
Article
Focus on randomised clinical trials
-
Article
Open AccessTargeting low-normal or high-normal mean arterial pressure after cardiac arrest and resuscitation: a randomised pilot trial
We aimed to determine the feasibility of targeting low-normal or high-normal mean arterial pressure (MAP) after out-of-hospital cardiac arrest (OHCA) and its effect on markers of neurological injury.
-
Article
Open AccessTargeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial
We assessed the effects of targeting low-normal or high-normal arterial carbon dioxide tension (PaCO2) and normoxia or moderate hyperoxia after out-of-hospital cardiac arrest (OHCA) on markers of cerebral and car...
-
Article
Premorbid functional status as a predictor of 1-year mortality and functional status in intensive care patients aged 80 years or older
We assessed the association between the premorbid functional status (PFS) and 1-year mortality and functional status of very old intensive care patients.
-
Article
Expert statement for the management of hypovolemia in sepsis
Hypovolemia is frequent in patients with sepsis and may contribute to worse outcome. The management of these patients is impeded by the low quality of the evidence for many of the specific components of the c...
-
Article
Focus on fluid therapy
-
Article
Fluid management in acute kidney injury
Acute kidney injury (AKI) and fluids are closely linked through oliguria, which is a marker of the former and a trigger for administration of the latter. Recent progress in this field has challenged the physio...
-
Article
Control groups in recent septic shock trials: a systematic review
The interpretation of septic shock trial data is profoundly affected by patients, control intervention, co-interventions and selected outcome measures. We evaluated the reporting of control groups in recent se...
-
Article
Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel-group, multicentre feasibility trial
We assessed the effects of a protocol restricting resuscitation fluid vs. a standard care protocol after initial resuscitation in intensive care unit (ICU) patients with septic shock.
-
Article
Vasopressors in shock: are we meeting our target and do we really understand what we are aiming at?
-
Article
Erratum to: Fluid challenges in intensive care: the FENICE study
-
Article
Open AccessFluid challenges in intensive care: the FENICE study
Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms...
