9 Result(s)
within
Viktor Petukhov
English
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Article
Open AccessGene panel selection for targeted spatial transcriptomics
Targeted spatial transcriptomics hold particular promise in analyzing complex tissues. Most such methods, however, measure only a limited panel of transcripts, which need to be selected in advance to inform on...
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Article
Open AccessReference-based cell type matching of in situ image-based spatial transcriptomics data on primary visual cortex of mouse brain
With the advent of multiplex fluorescence in situ hybridization (FISH) and in situ RNA sequencing technologies, spatial transcriptomics analysis is advancing rapidly, providing spatial location and gene expres...
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Article
Open AccessExpression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in recent years after SV2A was shown to be an epileptic drug target...
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Article
Cell segmentation in imaging-based spatial transcriptomics
Single-molecule spatial transcriptomics protocols based on in situ sequencing or multiplexed RNA fluorescent hybridization can reveal detailed tissue organization. However, distinguishing the boundaries of ind...
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Article
Open AccessAuthor Correction: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19869-5.
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Article
Open AccessIdentification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly understood due to the high complexity of affected neuronal circuits. To identify dysfunctional neuronal subtypes und...
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Article
Joint analysis of heterogeneous single-cell RNA-seq dataset collections
Single-cell RNA sequencing is often applied in study designs that include multiple individuals, conditions or tissues. To identify recurrent cell subpopulations in such heterogeneous collections, we developed ...
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Article
RNA velocity of single cells
RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput1. However, this approach cap...
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Article
Open AccessdropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments
Recent single-cell RNA-seq protocols based on droplet microfluidics use massively multiplexed barcoding to enable simultaneous measurements of transcriptomes for thousands of individual cells. The increasing c...
