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Article
Open AccessApelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin ...
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Article
Open Access3D histopathology of human tumours by fast clearing and ultramicroscopy
Here, we describe a novel approach that allows pathologists to three-dimensionally analyse malignant tissues, including the tumour-host tissue interface. Our visualization technique utilizes a combination of u...
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Article
Open AccessRole of (myo)fibroblasts in the development of vascular and connective tissue structure of the C38 colorectal cancer in mice
It remains unclear if the vascular and connective tissue structures of primary and metastatic tumors are intrinsically determined or whether these characteristics are defined by the host tissue. Therefore we e...
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Article
Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations
BRAF and NRAS are the two most frequent oncogenic driver mutations in melanoma and are pivotal components of both the EGF and FGF signaling network. Accordingly, we investigated the effect of BRAF and NRAS onc...
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Article
Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes
The 2-acetaminofluorene/partial hepatectomy (AAF/Phx) model is widely used to induce oval/progenitor cell proliferation in the rat liver. We have used this model to study the impact of a primary hepatocyte mit...
