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Chapter
Cancer Angiogenesis and Its Master Regulator Perlecan
Angiogenesis and vasculogenesis are not only indispensable for normal tissue growth and regeneration but also particularly vital for tumors. As without sufficient blood supply that provides nutrients, tumor ce...
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Chapter
The Role of Decorin in Cancer
The dynamic interactions between the tumor cells and their microenvironment consisting of stroma cells and extracellular matrix play a crucial role in cancer development. Decorin, a chondroitin sulfate/dermata...
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Chapter
The Mystery of Syndecan-1 in Tumor Development and Progression
Syndecan-1, a cell surface heparan sulfate proteoglycan, participates in a multitude of cellular processes, and it acts as a “fine tuner of cellular signaling.” Syndecan-1 is present in most epithelial tissues...
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Article
Open AccessSyndecan-1 in Liver Diseases
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expr...
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Article
Open AccessInhibitory Effect of (2R)-1-(1-Benzofuran-2-yl)-N-propylpentan-2-amine on Lung Adenocarcinoma
BPAP is a potent enhancer substance with catecholaminergic and serotoninergic activity in the brain. It was discovered that it is also effective against certain types of experimental cancers, showing the most ...
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Chapter
Decorin in the Tumor Microenvironment
The tumor microenvironment plays a determining role in cancer development through a plethora of interactions between the extracellular matrix and tumor cells. Decorin is a prototype member of the SLRP family f...
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Article
Chronic Hyperglycaemia Induced Alterations of Hepatic Stellate Cells Differ from the Effect of TGFB1, and Point toward Metabolic Stress
The deleterious effect of hyperglycemia on the biology of the liver is supported by clinical evidence. It can promote the development of fatty liver, liver fibrosis, even liver cancer as complication of diabet...
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Article
Open AccessDiethylnitrosamine induces lung adenocarcinoma in FVB/N mouse
Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with...
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Article
Systematic Investigation of Expression of G2/M Transition Genes Reveals CDC25 Alteration in Nonfunctioning Pituitary Adenomas
Dysregulation of G1/S checkpoint of cell cycle has been reported in pituitary adenomas. In addition, our previous finding showing that deregulation of Wee1 kinase by microRNAs together with other studies demon...
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Article
Response of Hepatic Stellate Cells to TGFB1 Differs from the Response of Myofibroblasts. Decorin Protects against the Action of Growth Factor
Regardless to the exact nature of damage, hepatic stellate cells (HSCs) and other non-parenchymal liver cells transform to activated myofibroblasts, synthesizing the accumulating extracellular matrix (ECM) pro...
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Article
Open AccessFluorescence activated cell sorting followed by small RNA sequencing reveals stable microRNA expression during cell cycle progression
Previously, drug-based synchronization procedures were used for characterizing the cell cycle dependent transcriptional program. However, these synchronization methods result in growth imbalance and alteration...
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Article
Dysregulation of microRNA Expression in Human Cervical Preneoplastic and Neoplastic Lesions
Data discussed in recent reviews demonstrated that dysregulation of microRNA (miRNA) expression profiles occurs during cervical carcinogenesis and characteristic up- or downregulation of certain miRNAs might b...
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Article
Open AccessRemodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression
Comparison of tissue microarray results of 29 cervical cancer and 27 normal cervix tissue samples using immunohistochemistry revealed considerable reorganization of the fibrillar stroma of these tumors.
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Article
Treatment of Refractory Hairy Cell Leukemia with a BRAF-inhibitor: Lessons to be Learnt
Hairy cell leukemia is a rare chronic lymphoproliferative disorder with indolent but progressive clinical course. Patients require treatment when they have significant cytopenia or recurrent infections. The go...
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Article
Antitumoral effects of 9-cis retinoic acid in adrenocortical cancer
The currently available medical treatment options of adrenocortical cancer (ACC) are limited. In our previous meta-analysis of adrenocortical tumor genomics data, ACC was associated with reduced retinoic acid ...
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Article
Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes
The 2-acetaminofluorene/partial hepatectomy (AAF/Phx) model is widely used to induce oval/progenitor cell proliferation in the rat liver. We have used this model to study the impact of a primary hepatocyte mit...
