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Article
Open AccessSARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
Coronavirus replication is associated with the remodeling of cellular membranes, resulting in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified as a putative portal for viral...
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Article
Open AccessZika virus prM protein contains cholesterol binding motifs required for virus entry and assembly
For successful infection of host cells and virion production, enveloped viruses, including Zika virus (ZIKV), extensively rely on cellular lipids. However, how virus protein–lipid interactions contribute to th...
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Article
Open AccessSARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
SARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, indiv...
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Article
Open AccessConvergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation
Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are morphologically analogous to DMVs formed during autopha...
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Article
Open AccessThe UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed individuals. Here, we elucidate a mechanism supporting the persistence of human adenovirus (AdV), a virus that can kill immu...
