-
Chapter
Neuroblastoma Epigenetic Landscape: Drugging Opportunities
The epigenetic machinery interprets cell intrinsic and extrinsic signals in a dynamic yet reversible process and is recruited to specific genes to implement an ordered lineage-specifying program when a stem ce...
-
Article
Open AccessRecapitulating thyroid cancer histotypes through engineering embryonic stem cells
Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryon...
-
Article
Open AccessEffective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
Breast cancer (BC) is the second cause of cancer-related deceases in the worldwide female population. Despite the successful treatment advances, 25% of BC develops resistance to current therapeutic regimens, t...
-
Article
Open AccessAdipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one of the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer cells with metastatic prope...
-
Article
Open AccessTargeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
Despite intense research and clinical efforts, patients affected by advanced colorectal cancer (CRC) have still a poor prognosis. The discovery of colorectal (CR) cancer stem cell (CSC) as the cell compartment...
-
Article
Open AccessMicroenvironment in neuroblastoma: isolation and characterization of tumor-derived mesenchymal stromal cells
It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterize...
