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Neuroblastoma

Discoveries and Challenges

  • Book
  • © 2024

Overview

Editors:
  1. Shahab Asgharzadeh

    1. Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, USA

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  2. Frank Westermann

    1. Department of Neuroblastoma Genomics, German Cancer Research Center, Heidelberg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a synopsis of current clinical and basic research on neuroblastoma
  • Presents the state of the art regarding tumor microenvironment and targeted therapeutics such as immunotherapy
  • Edited and authored by recognized experts in the field

Part of the book series: Pediatric Oncology (PEDIATRICO)

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About this book

This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in kee** with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma.

Keywords

Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Epidemiology, Presentation, and Evaluation

    • Rochelle Bagatell, Margaret Macy
    Pages 1-13

  3. Advanced Pathology Classification Toward Precision Stratification of Neuroblastic Tumors

    • Hiroyuki Shimada, Naohiko Ikegaki
    Pages 15-31

  4. Genetic Predisposition

    • Apexa Modi, Emily Blauel, Sharon J. Diskin
    Pages 33-51

  5. Somatic Genomic Alterations in Neuroblastoma

    • Pauline Depuydt, Gudrun Schleiermacher, Katleen De Preter
    Pages 53-69

  6. Neuroblastoma Epigenetic Landscape: Drugging Opportunities

    • Veronica Veschi, Kaat Durinck, Carol J. Thiele, Frank Speleman
    Pages 71-95

  7. The Genetic Basis of the Divergent Clinical Courses in Neuroblastoma

    • Carolina Rosswog, Matthias Fischer
    Pages 97-109

  8. Developmental Programs in Neuroblastoma

    • Selina Jansky, Frank Westermann
    Pages 111-122

  9. Neuroblastoma Tumor Microenvironment: Innate and Adaptive Immunity

    • Michael Zobel, Shahab Asgharzadeh
    Pages 123-141

  10. Neuroblastoma Tumor Microenvironment: Non-Immune Cells and Exosomes

    • Lucia Borriello, Laurence Blavier, Yves A. DeClerck
    Pages 143-153

  11. Metastatic Disease Burden

    • Araz Marachelian, Meredith S. Irwin
    Pages 155-165

  12. Therapeutically Actionable Genetic Aberrations

    • Monica Pomaville, Rani E. George
    Pages 167-180

  13. Re-Engaging the Immune System: Immunotherapy for Neuroblastoma

    • Miho Nakajima, Nai-Kong V. Cheung
    Pages 181-196

  14. Future of Clinical Trials and Application of Precision Medicine

    • Theresa Thole, Angelika Eggert
    Pages 197-215

  15. Future Aspects of Neuroblastoma Research

    • Frank Westermann, Shahab Asgharzadeh
    Pages 217-219
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Editors and Affiliations

  • Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, USA

    Shahab Asgharzadeh

  • Department of Neuroblastoma Genomics, German Cancer Research Center, Heidelberg, Germany

    Frank Westermann

About the editors

​Shahab Asgharzadeh MD, Children’s Hospital Los Angeles, Department of Pediatrics, Los Angeles, CA, USA 
Frank Westermann MD, German Cancer Research Center, Department: Neuroblastoma Genomics, Heidelberg, Germany

Bibliographic Information

  • Book Title: Neuroblastoma

  • Book Subtitle: Discoveries and Challenges

  • Editors: Shahab Asgharzadeh, Frank Westermann

  • Series Title: Pediatric Oncology

  • DOI: https://doi.org/10.1007/978-3-031-51292-6

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2024

  • Hardcover ISBN: 978-3-031-51291-9Published: 22 May 2024

  • Softcover ISBN: 978-3-031-51294-0Due: 25 June 2024

  • eBook ISBN: 978-3-031-51292-6Published: 21 May 2024

  • Series ISSN: 1613-5318

  • Series E-ISSN: 2191-0812

  • Edition Number: 1

  • Number of Pages: X, 219

  • Number of Illustrations: 1 b/w illustrations, 20 illustrations in colour

  • Topics: Oncology, Pediatrics, Neurology

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