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Article
Exposure to ethanol during neurodevelopment modifies crucial offspring rat brain enzyme activities in a region-specific manner
The experimental simulation of conditions falling within “the fetal alcohol spectrum disorder” (FASD) requires the maternal exposure to ethanol (EtOH) during crucial neurodevelopmental periods; EtOH has been l...
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Article
Experimentally-induced maternal hypothyroidism alters crucial enzyme activities in the frontal cortex and hippocampus of the offspring rat
Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the develo** central nervous system (CNS), and is associated with the establishment ...
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Article
Postnuclear Supernatants of Rat Brain Regions as Substrates for the In Vitro Assessment of Cadmium-Induced Neurotoxicity on Acetylcholinesterase Activity
Acetylcholinesterase (AChE) activity is thought to be a major neurotoxicity biomarker. Considering the recently highlighted controversy over the use of AChE activity as a biomarker for the neurotoxicity induce...
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Article
Developmental neurotoxicity of cadmium on enzyme activities of crucial offspring rat brain regions
Cadmium (Cd) is an environmental contaminant known to exert significant neurotoxic effects on both humans and experimental animals. The aim of this study was to shed more light on the effects of gestational (i...
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Article
Experimentally-induced Wernicke’s encephalopathy modifies crucial rat brain parameters: the importance of Na+,K+-ATPase and a potentially neuroprotective role for antioxidant supplementation
Wernicke’s encephalopathy (WE) is a serious neuropsychiatric syndrome caused by chronic alcoholism and thiamine (T) deficiency. Our aim was to shed more light on the pathophysiology of WE, by introducing a mod...
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Article
Hepatic Injury Due to Combined Choline-Deprivation and Thioacetamide Administration: An Experimental Approach to Liver Diseases
The induction of prolonged choline-deprivation (CD) in rats receiving thioacetamide (TAA) is an experimental approach of mild hepatotoxicity that could resemble commonly presented cases in clinical practice (i...
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Article
Activation of acetylcholinesterase after U-74389G administration in a porcine model of intracerebral hemorrhage
Spontaneous intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes. Despite high incidence, morbidity and mortality, the precise pathophysiology of spontaneous ICH is not fully understood, while the...
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Article
Combined thirty-day exposure to thioacetamide and choline-deprivation alters serum antioxidant status and crucial brain enzyme activities in adult rats
Choline (Ch) is an essential nutrient that seems to be involved in a wide variety of metabolic reactions and functions that affect the nervous system, while thioacetamide (TAA) is a well-known hepatotoxic agen...
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Article
Effects of hyper- and hypothyroidism on acetylcholinesterase, (Na+, K+)- and Mg 2+ -ATPase activities of adult rat hypothalamus and cerebellum
Thyroid hormones (THs) are recognized as key metabolic hormones, and the metabolic rate increases in hyperthyroidism, while it decreases in hypothyroidism. The aim of this work was to investigate how changes i...
