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  1. No Access

    Article

    Challenges in conducting genetic analyses based on data-driven classification of major depressive disorder

    V-P Mäkinen in Molecular Psychiatry (2018)

  2. Article

    Open Access

    Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity

    Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the...

    A Couto Alves, B Valcarcel, V-P Mäkinen… in International Journal of Obesity (2017)

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  3. No Access

    Article

    Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses

    Accumulating evidence suggests that serum lipids are associated with cognitive decline and dementias. However, majority of the existing information concerns only serum total cholesterol (TC) and data at the le...

    T. Tukiainen, P. Jylänki, V. -P. Mäkinen… in The journal of nutrition, health & aging (2012)

  4. Article

    Open Access

    Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

    Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment a...

    F. M. van der Kloet, F. W. A. Tempels, N. Ismail, R. van der Heijden… in Metabolomics (2012)

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  5. Article

    Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes

    Activation of the receptor for AGE (RAGE) is implicated in the development and progression of vascular complications of diabetes. In this study, we explore factors and mortality outcomes associated with solubl...

    M. C. Thomas, J. Söderlund, M. Lehto, V.-P. Mäkinen, J. L. Moran… in Diabetologia (2011)

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  6. Article

    Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

    We hypothesised that the blunted baroreflex sensitivity (BRS) typical of type 1 diabetes is caused by a higher degree of tissue hypoxia in diabetes, and tested whether oxygen increased BRS and ventilation less...

    L. Bernardi, M. Rosengård-Bärlund, A. Sandelin, V. P. Mäkinen, C. Forsblom… in Diabetologia (2011)

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  7. Article

    Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

    We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes.

    N. Tolonen, C. Forsblom, L. Thorn, J. Wadén, M. Rosengård-Bärlund… in Diabetologia (2009)

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  8. Article

    Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy

    Substantial evidence exists for the involvement of the renin–angiotensin system (RAS) in diabetic nephropathy. Angiotensin I converting enzyme 2 (ACE2), a new component of the RAS, has been implicated in kidne...

    S. Fröjdö, L. Sjölind, M. Parkkonen, V.-P. Mäkinen, R. Kilpikari… in Diabetologia (2005)

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