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Article
The Heart Failure with Preserved Ejection Fraction Conundrum—Redefining the Problem and Finding Common Ground?
Heart failure with preserved ejection fraction (HFpEF) or diastolic heart failure (DHF) makes up more than half of all congestive heart failure presentations (CHF). With an ageing population, the case load and...
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Article
Open AccessLight sfermion interplay in the 125 GeV MSSM Higgs production and decay at the LHC
We study the effects from light sfermions on the lightest Higgs boson production and decay at the Large Hadron Collider (LHC) within the Minimal Supersymmetric Standard Model (MSSM). We find that the scenario ...
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Article
Open AccessReasons for non-uptake and subsequent participation in the NHS Bowel Cancer Screening Programme: a qualitative study
Screening for bowel cancer using the guaiac faecal occult blood test offered by the NHS Bowel Cancer Screening Programme (BCSP) is taken up by 54% of the eligible population. Uptake ranges from 35% in the most...
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Article
Molecular characterization of calcineurin B from the non-virulent Trypanosoma rangeli kinetoplastid indicates high gene conservation
Calcineurin B, the regulatory subunit of calcineurin, a serine/threonine protein phosphatase, is highly conserved throughout the evolutionary scale including trypanosomatids such as Trypanosoma cruzi, and Leishma...
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Article
Open AccessMultiple Higgs and vector boson production beyond the Standard Model
If the electroweak symmetry breaking is originated from a strongly coupled sector, as for instance in composite Higgs models, the Higgs boson couplings can deviate from their Standard Model values. In such cas...
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Article
A functional and morphological approach to evaluate the vertical migration of estuarine intertidal nematodes during a tidal cycle
We tested herein the hypothesis that exposure time significantly contributes to the vertical distribution profile of nematodes during a tidal cycle as a function of distinct feeding and locomotion behaviors, c...
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Article
Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy?
Hyperfiltration is widely regarded as a contributing factor to the development of microalbuminuria and progressive nephropathy in type 1 diabetes. However, recent studies have questioned this conclusion.
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Article
Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes
Activation of the receptor for AGE (RAGE) is implicated in the development and progression of vascular complications of diabetes. In this study, we explore factors and mortality outcomes associated with solubl...
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Article
Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice
Formation of AGEs is increased in the diabetic milieu, which contributes to accelerated atherogenesis. We studied whether delayed treatment with AGE-inhibiting compounds, alagebrium chloride and pyridoxamine d...
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Article
Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor
The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the...
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Article
Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury
Diabetic nephropathy is an inflammatory disease with prominent leucocyte infiltration of the kidneys. While the importance of macrophages in diabetic renal injury has been clearly demonstrated, the role of lym...
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Article
Open AccessAssessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women
The aim of this study was to examine whether waist circumference (WC) or WHR improve diabetes prediction beyond body mass index in older men and women, and to define optimal cut-off points.
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Article
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice
There is convincing evidence that the endothelin system contributes to diabetic nephropathy and cardiovascular disease. This study aimed to assess the effects of the non-peptidergic endothelin receptor A (ETA)...
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Article
Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
Macrophage-mediated renal injury plays an important role in the development of diabetic nephropathy. Colony-stimulating factor (CSF)-1 is a cytokine that is produced in diabetic kidneys and promotes macrophage...
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Article
Potential reno-protective effects of a gluten-free diet in type 1 diabetes
Coeliac disease is common in type 1 diabetes. It is managed with a gluten-free diet, characterised by foods low in AGEs. We hypothesised that this diet would lead to lower plasma AGEs and be associated with re...
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Article
Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice
Obesity and diabetes are associated with increased intracellular p38 mitogen-activated protein kinase (MAPK) signalling, which may promote tissue inflammation and injury. Activation of p38 MAPK can be induced ...
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Article
Method to evaluate liberation characteristics of feed in a jigging plant
The roles of pulsating mechanisms such as the amplitude and frequency of the jig cycle are well established in jigging. Also well established are the roles of the size ratio and the volume fraction of the feed...
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Reference Work Entry In depth
Rove Beetles (Coleoptera: Staphylinidae)
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Article
Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties
AGE contribute to the pathogenesis of diabetic complications, including dyslipidaemia and atherosclerosis. However, the precise mechanisms remain to be established. In the present study, we examined whether AG...
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Article
Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods
We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes.
