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Article
Open Accessγ-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core
The AMPA-type ionotropic glutamate receptor mediates fast excitatory neurotransmission in the brain. A variety of auxiliary subunits regulate its gating properties, assembly, and trafficking, but it is unknown...
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Article
Open AccessAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled consti...
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Article
Native GABAB receptors are heteromultimers with a family of auxiliary subunits
A proteomics study of GABAB receptors, the receptors for γ-aminobutyric acid, the main inhibitory neurotransmitter in the brain, throws new light on the origin of their functional diversity. Rather than being het...
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Article
Neuronal nicotinic acetylcholine receptors and autosomal dominant nocturnal frontal lobe epilepsy: a critical review
Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a distinct human epileptic syndrome. In some families, it is associated with mutations of the α4 or the β2 subunit of the neuronal nicotinic acet...