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Chapter
Hydrogen infrastructures — Networks and storage
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Chapter
Wasserstoffinfrastrukturen – Netze und Speicher
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Article
Open AccessDifferential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain
Using auditory discrimination learning in gerbils, we have previously shown that activation of auditory-cortical D1/D5 dopamine receptors facilitates mTOR-mediated, protein synthesis-dependent mechanisms of me...
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Article
Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
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Article
Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
The key role of APP in the pathogenesis of Alzheimer disease is well established. However, postnatal lethality of double knockout mice has so far precluded the analysis of the physiological functions of APP an...
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Article
Open AccessComparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression
Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used orga...
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Article
The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models
APP, APLP1, and APLP2 form a family of mammalian membrane proteins with unknown function. APP, however, plays a key role in the molecular pathology of Alzheimer’s disease (AD), indicating that it is somehow in...
