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Neurotrophins and Their Receptors Mediate Processes of Metaplasticity and Long-Term Memory Formation
In this chapter, a special class of small secretory peptides, the neurotrophins and their receptors, will be introduced as candidate molecules in order to calibrate and possibly consolidate memory contents. Nu...
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Handlungsempfehlungen zur somatischen Gentherapie, Keimbahninterventionen und Zelltherapie
Der umfassende Aufschwung der klinischen Gentherapie seit ca. 2010 (vgl. „Fünfter Gentechnologiebericht“ ) hat sich in den vergangenen Jahren fortgesetzt und konsolidiert. Der daraus resultierende breite Einst...
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Article
Open AccessOpening the box of PANTHORA in Alzheimer’s disease
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Article
Open AccessNeuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling
Maturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and defects in synaptic maturation may contribute to neurodevelopmental disorde...
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Article
Author Correction: A guiding map for inflammation
A Correction to this paper has been published: https://doi.org/10.1038/ni.3790
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Article
Open AccessBDNF signaling during the lifetime of dendritic spines
Dendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during developme...
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Article
Open AccessSignaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology
Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer’s disease (AD) and is directly correlated with the cognitive decline typical of thi...
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Lernen durch Lehren: Teach It Forward auf drei Wegen
Der Kern von Lernen durch Lehren ist, dass Studierende der MINT-Fächer an der Technischen Universität Braunschweig durch einen Perspektivenwechsel – von der Rolle des passiv Lernenden in die des aktiv Lehrend...
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Article
Cell type-specific effects of BDNF in modulating dendritic architecture of hippocampal neurons
Brain-derived neurotrophin factor (BDNF) has been implicated in neuronal survival, differentiation and activity-dependent synaptic plasticity in the central nervous system. It was suggested that during postnat...
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Vom Kapiertrieb des Menschen: Motivation und Konzentration aus Sicht eines Lernforschers
Belohnung fördert die Motivation. Dieser Grundsatz erscheint jedem einleuchtend und vollkommen nachvollziehbar, aber manchmal muss man als Wissenschaftler auch das Offensichtliche belegen. Um die Allgemeingült...
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A guiding map for inflammation
Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.
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Article
Not just amyloid: physiological functions of the amyloid precursor protein family
Amyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in th...
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Article
Open AccessFE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation
The FE65 adaptor proteins (FE65, FE65L1 and FE65L2) bind proteins that function in diverse cellular pathways and are essential for specific biological processes. Mice lacking both FE65 and FE65L1 exhibit ectop...
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Article
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is characterized by synaptic failure, dendritic and axonal atrophy, neuronal death and progressive loss of cognitive functions. It is commonly assumed that these deficits arise due to ...
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Article
Correction: Corrigendum: Fluorescence nanoscopy by polarization modulation and polarization angle narrowing
Nat. Methods 11, 579–584 (2014); published online 6 April 2014; corrected after print 9 December 2015 In the version of this article initially published, it was not clearly indicated that all the results obtai...
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Reply to "Polarization modulation adds little additional information to super-resolution fluorescence microscopy"
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Article
Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
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Chapter
BDNF and TrkB-Mediated Signalling Supports Processes of Metaplasticity and Long-Term Memory Formation
In this chapter a special class of small secretory peptides, the neurotrophins, will be introduced as candidate molecules in order to calibrate and possibly consolidate memory contents. Numerous reports show t...
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Article
Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
The key role of APP in the pathogenesis of Alzheimer disease is well established. However, postnatal lethality of double knockout mice has so far precluded the analysis of the physiological functions of APP an...
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Article
Fluorescence nanoscopy by polarization modulation and polarization angle narrowing
Excitation using rotating polarized light and detection of periodic signals from rectangular nanoareas allows widef-ield super-resolution imaging of biological structures in cells and in tissue with reduced ba...
