50 Result(s)
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Ulrich H. von Andrian
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Article
Open AccessLung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis
Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed single cell RNA-sequen...
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Article
Open AccessConditions that promote transcellular neutrophil migration in vivo
Circulating leukocytes enter tissue either through endothelial junctions (paracellular) or via a pore through the body of endothelial cells (transcellular). We have previously shown that genetically replacing ...
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Article
No pain, no gain — how nociceptors orchestrate tissue repair
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Article
Open AccessSlow integrin-dependent migration organizes networks of tissue-resident mast cells
Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction1. Many immune cells do not necessarily r...
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Article
Open AccessSpecialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules
T cells undergo rigorous selection in the thymus to ensure self-tolerance and prevent autoimmunity, with this process requiring innocuous self-antigens (Ags) to be presented to thymocytes. Self-Ags are either ...
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Article
Open AccessFcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties of DCs (nAPC) are observed in human diseases and a...
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Article
NK cell memory: discovery of a mystery
Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can...
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Article
Open AccessCosmc controls B cell homing
The molecular mechanisms regulating lymphocyte homing into lymph nodes are only partly understood. Here, we report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein...
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Chapter and Conference Paper
Visualizing the Immune Response to Infections
The immune system is tasked with detecting and responding to infections anywhere in the body. To accomplish this task requires the coordinated migration of immune cells and highly dynamic interactions of the m...
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Article
Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex
Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex, extending from the spinal cord to the adrenal glands, where it ...
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Article
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis
Genetic polymorphisms affect expression of the atypical chemokine receptor ACKR1 (Duffy) on nucleated erythrocyte precursors. Rot and colleagues show that loss of its expression alters hematopoiesis, yielding ...
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Article
Illuminating vital surface molecules of symbionts in health and disease
The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response1,2. Recent studies have highlighted the unique and important responses ...
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Article
Open AccessDifferential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues
Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This se...
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Article
In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria
Fluorescently labeled commensal microbes can be tracked in vivo, allowing visualization of host–microbiota interactions in real time.
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Article
Antigen-specific NK cell memory in rhesus macaques
Recent studies have shown features of antigen-specific memory in mouse NK cells, but it is unclear whether this phenomenon also exists in primates. Barouch and colleagues provide evidence for robust, durable, ...
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Article
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in vivo by durably silencing mult...
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Article
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
In mice, it is possible to induce a psoriasis-like condition by applying imiquimod; here, the production of interleukin-23 that is stimulated by such skin inflammation is shown to depend on the interaction of ...
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Article
Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Weninger and colleagues show that perivascular macrophages are critical for neutrophil migration into skin infected with Staphylococcus aureus and that the pathogen uses hemolysin-dependent killing of these cells...
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Article
HIV-infected T cells are migratory vehicles for viral dissemination
Using intravital microscopy, this study visualizes HIV-1-infected T cells within the lymph nodes of humanized mice, demonstrating that infected cells have reduced motility and long membrane processes; treating...
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Article
Natural killer cell memory
Natural killer (NK) cells are bone marrow–derived granular lymphocytes that have a key role in immune defense against viral and bacterial infections and malignancies. NK cells are traditionally defined as cell...
