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  1. No Access

    Article

    Illuminating vital surface molecules of symbionts in health and disease

    The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response1,2. Recent studies have highlighted the unique and important responses ...

    Jason E. Hudak, David Alvarez, Ashwin Skelly, Ulrich H. von Andrian… in Nature Microbiology (2017)

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    Article

    In vivo imaging and tracking of host–microbiota interactions via metabolic labeling of gut anaerobic bacteria

    Fluorescently labeled commensal microbes can be tracked in vivo, allowing visualization of host–microbiota interactions in real time.

    Naama Geva-Zatorsky, David Alvarez, Jason E Hudak, Nicola C Reading… in Nature Medicine (2015)

  3. No Access

    Article

    The cancer glycocalyx mechanically primes integrin-mediated growth and survival

    Malignancy is associated with altered expression of glycans and glycoproteins that contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature, which revealed that metastatic tumo...

    Matthew J. Paszek, Christopher C. DuFort, Olivier Rossier, Russell Bainer… in Nature (2014)

  4. No Access

    Article

    Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

    Defined phospholipid-functionalized glycopolymers serve as a new tool to identify the mechanistic connection between hypersialylation and immunoprotection, where hypersialylation of tumor cells subverts the im...

    Jason E Hudak, Stephen M Canham, Carolyn R Bertozzi in Nature Chemical Biology (2014)