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Article
Open AccessMorphological and molecular characteristics of HER2 amplified urothelial bladder cancer
Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially profit from these therapie...
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Article
Open AccessmiR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas
Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) p...
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Article
Zonation of Hepatic Bile Salt Transporters
Pericentral and periportal hepatocytes differ in their capacity to eliminate and velocity of eliminating bile acids and other organic anions. We wonder whether differences in the distribution of anion transpor...
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Chapter and Conference Paper
Multimodale Therapie des Analkarzinoms
Zielsetzung: Die Radio-Chemo-Therapie gilt als Therapie der Wahl zur Behandlung des Analkarzinoms. Als Qualitätsmerkmale dieser Therapie gelten eine möglichst hohe Heilungsrate und Erhalt bestmög...
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Chapter and Conference Paper
Chirurgisch relevante Komorbiditäten: Kooperationsfähigkeit / Surgically Relevant Comorbidity: Cooperation
The ability to cooperate represents an important prognostic factor for the result of any surgical therapy. Cooperation relies on a trustful relationship between physician and patient and requires active partic...
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Article
Abolished laser-evoked potentials and normal blink reflex in midlateral medullary infarction
We investigated two patients presenting with the rare finding of almost isolated hemianalgesia with a sensory level on the contralateral side sparing the face. Clinical findings, electrophysiological studies ...
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Article
Differenzierung von schmerz- und morphinbedingter Beeinträchtigung kognitiver Leistungen und subjektiver Befindlichkeit bei Knochenmarktransplantationspatienten
Zielsetzung: Eine kontinuierliche parenterale Opioidanalgesie ist in der Regel erforderlich, um äußerst schmerzhafte Entzündungen der Schleimhäute (Mukositis) zu behandeln, die Patienten ...
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Chapter and Conference Paper
Verschlußikterus — Auswirkungen auf Leber- und andere Organfunktionen sowie Operationsrisiko
Bile duct obstruction affects microsomal (cytochrome P450) and mitochondrial (adenosine triphosphate, ATP) liver function as well as RES clearance. Increased postoperative morbidity and mortality are linked to...
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Article
Hepatic passage of bile acids increases oxygen uptake by perfused rat liver
It has been claimed that the hepatic passage of conjugated bile acids does not increase oxygen uptake by the isolated perfused rat liver. We studied a variety of bile acids in the single-pass perfused rat live...
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Article
Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liver
The infusion of taurolithocholate (TLC) in vivo or in the isolated perfused liver of the rat causes cholestasis and cellular necrosis. In order to analyze the protective effect of bile salts differing in numbe...
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Chapter and Conference Paper
Ultrastrukturelle Veränderungen im Ganglion spirale cochleae nach einem Zinkmangel
Verschiedene Autoren berichteten in den letzten Jahren über Zusammenhänge zwischen dem Spurenelement Zink und der Funktion des Innenohres und der Hörbahn. So fanden Löhle et al. 1982 eine Hörstörung bei Patien...
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Chapter
Lack of Hormonal Response in Liver Cells from Rats with Extrahepatic Cholestasis
Gallensäuren verändern Membranen und führen in vitro zu einem Verlust der Hormonantwort. Die glukoneogenetische Kapazität isolierter Leberzellen von Ratten mit extra-hepatischer Cholestase und deren hormonelle...
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Chapter and Conference Paper
Gastroenterologie
Nach Oberbauchoperationen wird zur Verhütung einer postoperativen Magenatonie häufig für einige Tage eine Magensonde gelegt. Die klinische Erfahrung zeigt, daß es nach längerer Liegezeit einer Magensonde zur E...
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Chapter and Conference Paper
Pathogenesis and Pathophysiology of Chronic Subdural Haematoma
The chronic subdural hematoma is defined as a clearly encapsulated accumulation of fluid between the dura and arachnoid membrane (11), generally occurring after slight brain trauma, often without apparent cause (
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Chapter and Conference Paper
Pathognesis of Chronic Subdural Hematoma. ICP, Biochemical and Morphological Findings
The chronic subdural hematoma is characterized by a clearly encapsulated accumulation of fluid between the dura and arachnoidea (6). Despite its large space-occupation, clinical symptoms only slowly become app...