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  1. Article

    Open Access

    Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity

    All-trans retinoic acid (ATRA), a pan-retinoic acid receptor (RAR) agonist, is, along with other retinoids, a promising therapeutic agent for the treatment of a variety of solid tumors. On the one hand, preclinic...

    D Brigger, A M Schläfli, E Garattini, M P Tschan in Cell Death & Disease (2015)

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  2. Article

    Open Access

    Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation

    While many anticancer therapies aim to target the death of tumor cells, sophisticated resistance mechanisms in the tumor cells prevent cell death induction. In particular enzymes of the glutathion-S-transferas...

    A Brockmann, A Bluwstein, A Kögel, S May, A Marx, M P Tschan… in Cell Death & Disease (2015)

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  3. Article

    p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells

    The p62/SQSTM1 adapter protein has an important role in the regulation of several key signaling pathways and helps transport ubiquitinated proteins to the autophagosomes and proteasome for degradation. Here, w...

    A Trocoli, P Bensadoun, E Richard, G Labrunie, F Merhi… in Cell Death & Differentiation (2014)

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  4. Article

    Open Access

    WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells

    Members of the WD-repeat protein interacting with phosphoinositides (WIPI) family are phosphatidylinositol 3-phosphate (PI3P) effectors that are essential for the formation of autophagosomes. Autophagosomes, u...

    D Brigger, T Proikas-Cezanne, M P Tschan in Cell Death & Disease (2014)

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  5. Article

    Open Access

    miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas

    Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is currently used for the treatment of glioblastoma (GBM) p...

    S Haemmig, U Baumgartner, A Glück, S Zbinden, M P Tschan… in Cell Death & Disease (2014)

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  6. Article

    p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

    p73, a member of the p53 tumor suppressor family, is involved in neurogenesis, sensory pathways, immunity, inflammation, and tumorigenesis. How p73 is able to participate in such a broad spectrum of different ...

    Z He, H Liu, M Agostini, S Yousefi, A Perren, M P Tschan… in Cell Death & Differentiation (2013)

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  7. No Access

    Article

    MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma

    The c-Src kinase regulates cancer cell invasion through inhibitor of DNA binding/differentiation 1 (ID1). Src and ID1 are frequently overexpressed in human lung adenocarcinoma. The current study aimed at ident...

    S I Rothschild, M P Tschan, E A Federzoni, R Jaggi, M F Fey, M Gugger… in Oncogene (2012)

  8. No Access

    Article

    The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1

    M Jenal, J Batliner, V A Reddy, T Haferlach, A Tobler, M F Fey, B E Torbett… in Leukemia (2010)

  9. No Access

    Article

    DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function

    Death-associated protein kinase 2 (DAPK2) belongs to a family of proapoptotic Ca2+/calmodulin-regulated serine/threonine kinases. We recently identified DAPK2 as an enhancing factor during granulocytic differenti...

    A Britschgi, E Trinh, M Rizzi, M Jenal, A Ress, A Tobler, M F Fey, K Helin… in Oncogene (2008)

  10. No Access

    Article

    PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity

    The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-in...

    M P Tschan, V A Reddy, A Ress, G Arvidsson, M F Fey, B E Torbett in Oncogene (2008)

  11. No Access

    Article

    The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias

    M P Tschan, U Gullberg, D Shan, B E Torbett, M F Fey, A Tobler in Leukemia (2008)

  12. Article

    Erratum: T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery

    Correction to: Gene Therapy (2006) 13, 1480–1492. doi: 10.1038/sj.gt.3302801 Since the publication of the above article, the authors have noticed that Dr Steinberger and his affiliation were omitted. The corre...

    C H Swan, B Bühler, P Steinberger, M P Tschan, C F Barbas III, B E Torbett in Gene Therapy (2007)

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  13. No Access

    Article

    T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery

    CCR5 is the chemokine co-receptor for R5-tropic human immunodeficiency virus type 1 (HIV-1) isolates most often associated with primary infection. We have developed an HIV-1 self-inactivating vector, CAD-R5, c...

    C H Swan, B Bühler, M P Tschan, C F Barbas III, B E Torbett in Gene Therapy (2006)

  14. No Access

    Article

    Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

    The tumor suppressor gene hypermethylated in cancer 1 (HIC1), located on human chromosome 17p13.3, is frequently silenced in cancer by epigenetic mechanisms. Hypermethylated in cancer 1 belongs to the bric à brac...

    C Britschgi, M Rizzi, T J Grob, M P Tschan, B Hügli, V A Reddy, A-C Andres… in Oncogene (2006)