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Article
Open AccessAquarius is required for proper CtIP expression and homologous recombination repair
Accumulating evidence indicates that transcription is closely related to DNA damage formation and that the loss of RNA biogenesis factors causes genome instability. However, whether such factors are involved i...
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Article
Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression
Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the...
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Article
Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule
T cell activation is regulated by two distinct signals, signals one and two. Concanavalin A (ConA) is an antigen-independent mitogen and functions as signal one inducer, leading T cells to polyclonal prolifera...
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Protocol
Optimized Gene Silencing by Co-expression of Multiple shRNAs in a Single Vector
Currently, RNA interference technology is one of the most powerful tools in molecular biology and has been widely used in genetic manipulation. In addition to chemically synthesized small interfering RNA (siRN...
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Article
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene
XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucl...
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Article
A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts
CYCLOBUTANE pyrimidine dimers (CPDs) and pyrimidine (6–4) pyrimidone photoproducts ((6–4)photoproducts) are the two major classes of cytotoxic, mutagenic and carcinogenic DNA photoproducts produced by ultravio...