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  1. Article

    Open Access

    Aquarius is required for proper CtIP expression and homologous recombination repair

    Accumulating evidence indicates that transcription is closely related to DNA damage formation and that the loss of RNA biogenesis factors causes genome instability. However, whether such factors are involved i...

    Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto… in Scientific Reports (2017)

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  2. Article

    Rapid proliferation of activated lymph node CD4+ T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

    Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the...

    Takuya Mishima, Shoko Toda, Yoshiaki Ando… in Cellular & Molecular Biology Letters (2014)

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    Article

    Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule

    T cell activation is regulated by two distinct signals, signals one and two. Concanavalin A (ConA) is an antigen-independent mitogen and functions as signal one inducer, leading T cells to polyclonal prolifera...

    Yoshiaki Ando, Chika Yasuoka, Takuya Mishima… in In Vitro Cellular & Developmental Biology … (2014)

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    Optimized Gene Silencing by Co-expression of Multiple shRNAs in a Single Vector

    Currently, RNA interference technology is one of the most powerful tools in molecular biology and has been widely used in genetic manipulation. In addition to chemically synthesized small interfering RNA (siRN...

    Yasuhito Ishigaki, Akihiro Nagao, Tsukasa Matsunaga in RNA Interference (2010)

  5. No Access

    Article

    High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

    XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucl...

    Hironobu Nakane, Seiji Takeuchi, Shunsuke Yuba, Masafumi Saijo… in Nature (1995)

  6. No Access

    Article

    A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts

    CYCLOBUTANE pyrimidine dimers (CPDs) and pyrimidine (6–4) pyrimidone photoproducts ((6–4)photoproducts) are the two major classes of cytotoxic, mutagenic and carcinogenic DNA photoproducts produced by ultravio...

    Takeshi Todo, Hiroshi Takemori, Haruko Ryo, Makoto lhara, Tsukasa Matsunaga… in Nature (1993)