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Chapter and Conference Paper
Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats
We previously reported that ATP-sensitive potassium (KATP) channels regulate ductal constriction in response to oxygen [1]. Diazoxide is a KATP channel opener while the usefulness of diazoxide for hyperinsulinemi...
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Chapter and Conference Paper
Constriction of the Ductus Arteriosus with KATP Channel Inhibitors
The cause of fetal death by sulfonylureas (SUs), used for diabetes in pregnancy in the early 1960s, remained unsolved for decades. In 1993, Nakanishi discovered constriction of ductus arteriosus (DA) strips in...
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Chapter
Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel
The fetal patency and neonatal closure of the ductus arteriosus (DA) are regulated with oxygen and prostaglandins. The proposed oxygen sensors of fetal and neonatal DA include P450-endothelin and the Kv channe...
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Article
In Vivo Dilatation of the Ductus Arteriosus Induced by Furosemide in the Rat
Furosemide increases prostaglandin production and may be associated with patent ductus arteriosus (PDA). We aimed to clarify the in vivo ductus-dilating effects of furosemide in neonatal rats. Near-term rat pups ...
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Article
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
Noonan syndrome is characterized by short stature, facial dysmorphia and a wide spectrum of congenital heart defects1,2. Mutations of PTPN11, KRAS and SOS1 in the RAS-MAPK pathway cause ∼60% of cases of Noonan sy...
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Article
In Vivo Constriction of the Fetal and Neonatal Ductus Arteriosus by a Prostanoid EP4-Receptor Antagonist in Rats
Indomethacin is used to constrict the patent ductus arteriosus in premature infants. To clarify possible prostanoid receptor antagonists that can constrict the ductus, we studied in vivo constriction of the fetal...
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Article
In Vivo Dilation of Fetal and Neonatal Ductus Arteriosus by Inhibition of Phosphodiesterase-5 in Rats
A recent in vitro study showed that sildenafil, a type 5 phosphodiesterase inhibitor, dilated the constricted ductus arteriosus of neonatal rabbits. We studied the in vivo ductus-dilating effects of sildenafil in...
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Article
Ectopic expression of an embryonic skeletal myosin heavy chain in human fetal and Syrian hamster hearts
The mammalian heart is known to contain only two isoformic myosin heavy chain (MHC) genes, α and β. A previously uncharacterized MHC gene was isolated in Syrian hamster hearts (McCully et al., J Mol Biol 1991). W...
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Article
Inhibition of In Vivo Constriction of Fetal Ductus Arteriosus by Endothelin Receptor Blockade in Rats
The fetal ductus can be constricted by drugs, including cyclooxygenase inhibitors (indomethacin), nitric oxide synthesis antagonists [N-nitro-l-arginine monomethyl ester (l-NAME)], and glucocorticoid hormones (de...
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Article
The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses
The role of endothelin in oxygen-induced contraction remains controversial. The present study was designed to investigate the role of endothelin in O2-induced contraction in the isolated ductal preparation of ra...
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Article
The Effect of Vitamin A on Contraction of the Ductus Arteriosus in Fetal Rat
Endogenous retinoic acid may play a role in inducing smooth muscle differentiation in the fetal ductus arteriosus. Maternal administration of retinoic acid may accelerate the process. This study was designed t...
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Article
The Role of Nitric Oxide in Dilating the Fetal Ductus Arteriosus in Rats
Prostaglandin E is a major dilator of the fetal ductus arteriosus (DA), but the role of nitric in fetal ductal dilation has not been established. We studied the effects of a potent nitric oxide synthase inhibi...
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Article
Ultrastructural features of the myocardium of children with dilated cardiomyopathy
We analyzed the electron-microscopic features of endomyocardial biopsy from pediatric patients with dilated cardiomyopathy (DCM). The specimens examined were taken from the right ventricle of ten patients aged...
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Article
Molecular and clinical study of 183 patients with conotruncal anomaly face syndrome
To investigate molecular and clinical aspects of conotruncal anomaly face (CAF), we studied the correlation between deletion size and phenotype and the mode of inheritance in 183 conotruncal anomaly face syndr...
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Article
Accelerated Maturation of Fetal Ductus Arteriosus by Maternally Administered Vitamin A in Rats
Maturation of fetal ductus arteriosus is associated with increased constriction in response to maternally administered indomethacin. Recently retinoic acid has been shown to be important in development of the ...
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Article
Developmental Changes in the Effect of Acidosis on Contraction, Intracellular pH, and Calcium in the Rabbit Mesenteric Small Artery
The purpose of the present study was to determine developmental changes in the effect of respiratory acidosis on vascular smooth muscle contraction. Vessel diameter, intracellular pH (pHi), and calcium concentrat...
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Article
Effect of acidosis on contraction, intracellular pH, and calcium in the newborn and adult rabbit aorta
This study investigated the effect of acidosis on intracellular pH (pHi), intracellular calcium concentration ([Ca]i), and vascular contraction in the aorta of the newborn and adult rabbit. Isometric tension, pHi
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Chapter and Conference Paper
Balloon Angioplasty of Pulmonary Artery Following Arterial Switch Operation for Complete Transposition of the Great Arteries
Twenty-eight patients with transposition of the great arteries underwent 39 balloon angioplasty procedures after the arterial switch operation. The mean age at dilation was 4.5 years (range, 0.7–10 years). The...
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Article
Developmental Changes in the Contractile System of the Mesenteric Small Artery of Rabbit
This study investigated developmental changes in the contractile system of the mesenteric small arteries of the rabbit. Arteries about 1 mm in length and 100-250 μm in internal diameter were dissected out from...
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Chapter and Conference Paper
Arrhythmias in Left Isomerism
Three features of arrhythmias in left isomerism are reported. Atrial rhythm is characteristically multiple and tends to slow, corresponding to a poorly developed sinus node in left isomerism. Atrioventricular ...
