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Article
Comparison of continuous flow analysis and ion chromatography for determinations of nitrate, nitrite and phosphate ions in seawater and development of related seawater certified reference materials
Determinations of three nutrients (nitrate, nitrite and phosphate ions) in seawater were investigated by continuous flow analysis (CFA) based on colorimetry and ion chromatography (IC). The accuracies of those...
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Article
Compositional evolution of slab-derived fluids during ascent: implications from trace-element partition between hydrous melts and Cl-free or Cl-rich aqueous fluids
Slab-derived supercritical liquids separate into aqueous fluids and hydrous melts during their migration. Separated aqueous fluids further release melt components that cannot be dissolved during ascent. During...
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Article
Application of the relative molar sensitivity method using GC-FID to quantify safranal in saffron (Crocus sativus L.)
Safranal is one flavor component of saffron, which is used as a spice, food additive, and crude drug. In ISO3632, safranal is defined as the compound that contributes to the quality of saffron, and many quanti...
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Article
Open AccessCorrection to: Transarterial fiducial marker implantation for CyberKnife radiotherapy to treat pancreatic cancer: an experience with 14 cases
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Chapter
Regulation of Secondary Metabolites Through Signaling Molecules in Streptomyces
The bacterial genus Streptomyces is well characterized by an ability to produce a wide variety of secondary metabolites including antibiotics, anticancer agents, antiviral drugs, herbicides, pesticides, insectici...
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Article
Open AccessFLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells
FMS-like tyrosine kinase 3 (FLT3) in hematopoietic cells binds to its ligand at the plasma membrane (PM), then transduces growth signals. FLT3 gene alterations that lead the kinase to assume its permanently activ...
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Article
Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer’s Disease in Mouse Brain and Plasma
In this study, we developed an analytical method using LC-MS/MS for the simultaneous determination of five bile acids (BAs) that have been recently reported as candidate diagnostic biomarkers for Alzheimer's d...
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Article
Open AccessAberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer
Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recogniz...
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Article
Open AccessTransarterial fiducial marker implantation for CyberKnife radiotherapy to treat pancreatic cancer: an experience with 14 cases
The purpose of this study was to evaluate the safety and feasibility of transarterial fiducial marker implantation for CyberKnife radiotherapy to treat locally advanced pancreatic cancer.
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Article
Muraminomicins, new lipo-nucleoside antibiotics from Streptosporangium sp. SANK 60501-structure elucidations of muraminomicins and supply of the core component for derivatization
We screened for bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (MraY: EC 2.7.8.13) inhibitors with the aim of discovering novel antibiotics and observed inhibitory activity in the culture broth of an ...
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Article
Open AccessFirst-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors
Transient CD4+ T cell depletion led to the proliferation of tumor-specific CD8+ T cells in the draining lymph node and increased infiltration of PD-1+CD8+ T cells into the tumor, which resulted in strong anti-tum...
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Article
Open AccessLeft trisectionectomy combined with resection of the right hepatic vein and inferior vena cava after right hepatic vein embolization for advanced intrahepatic cholangiocarcinoma
When the inferior right hepatic vein (IRHV) is present, left hepatic trisectionectomy with resection of the right hepatic vein (RHV) is theoretically possible without reconstruction of the RHV. We here report ...
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Article
Open AccessUsefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery
Biliary tract cancer (BTC) is an aggressive type of malignant tumour. Even after radical resection, the risk of recurrence is still high, resulting in a poor prognosis. Here, we investigated the usefulness of ...
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Article
Open AccessProfiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification
We successfully determined the difference of immune microenvironments between pNENs and pancreatic ductal adenocarcinomas (PDACs), and the histology-dependent variability among pNENs using multispectral fluore...
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Article
Genetic improvement of xylose metabolism by enhancing the expression of pentose phosphate pathway genes in Saccharomyces cerevisiae IR-2 for high-temperature ethanol production
The pentose phosphate pathway (PPP) plays an important role in the efficiency of xylose fermentation during cellulosic ethanol production. In simultaneous saccharification and co-fermentation (SSCF), the optim...
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Article
New Japanese certified reference materials for electrolytic conductivity measurements
The National Metrology Institute of Japan (NMIJ) has established three certified reference materials (CRMs) in electrolytic conductivity with a primary Jones-type cell: aqueous solutions of potassium chloride ...
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Chapter
Quantitative Elemental Bioimaging Protocol Using Femtosecond-Laser Ablation-ICP-Mass Spectrometry Coupled with Glass Standard Reference Material
We have developed new analytical technique for the quantitative elemental imaging for trace elements using a femtosecond-laser ablation-ICP-mass spectrometry (fs-LA-ICP-MS). With the laser ablation under the f...
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Article
Requirement of interleukin 7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model
Induction of lymphopenia before adoptive transfer of T cells was followed by lymphopenia-induced proliferation (LIP) and generated a potent anti-tumor immune response in rodents and in a clinical setting. Pre...
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Article
Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device
Concentration of real tumor cells leaking into blood from cancer was attempted by a deterministic lateral displacement (DLD) microfluidic device. Spiked cultured cell line tumor cells are often used to verify ...
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Article
Open AccessCharacterization of the Kluyveromyces marxianus strain DMB1 YGL157w gene product as a broad specificity NADPH-dependent aldehyde reductase
The open reading frame YGL157w in the genome of the yeast Kluyveromyces marxianus strain DMB1 encodes a putative uncharacterized oxidoreductase. However, this protein shows 46% identity with the Saccharomyces cer...
