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Article
Open AccessWhole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma
The mechanism underlying the development of tumors, particularly at early stages, still remains mostly elusive. Here, we report whole-genome long and short read sequencing analysis of 76 lung cancers, focusing...
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Article
Open AccessPhasing analysis of lung cancer genomes using a long read sequencer
Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By the combinatory use of short and l...
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Article
Open AccessAberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer
Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recogniz...
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Protocol
Transcript Identification Through Long-Read Sequencing
RNA-seq using long-read sequencing, such as nanopore and SMRT (Single Molecule, Real-Time) sequencing, enabled the identification of the full-length structure of RNA molecules. Several tools for long-read RNA-...
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Article
K-Ar ages of the Quaternary basalts in the Jeongok area, the central part of Korean Peninsula
The Quaternary basalts along the Chugaryeong Fault zone in central part of the Korean Peninsula are composed of two stratigraphic units in the Jeongok area, calling the Chatan and Jeongok basalts. K-Ar analyse...
