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Article
Open AccessRepurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
The limited number of antifungals and the rising frequency of azole-resistant Candida species are growing challenges to human medicine. Drug repurposing signifies an appealing approach to enhance the activity of ...
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Open AccessOspemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities
Azole antifungals are vital therapeutic options for treating invasive mycotic infections. However, the emergence of azole-resistant isolates combined with limited therapeutic options presents a growing challen...
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Article
Open AccessAntibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans
Candida albicans is the fourth most common cause of systemic nosocomial infections, posing a significant risk in immunocompromised individuals. As the majority of systemic C. albicans infections stem from endogen...
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Open AccessInferring Gene Regulatory Networks from a Population of Yeast Segregants
Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide ...
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Article
Erratum: Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore
Nat. Cell Biol. 14, 614–624 (2012); published online 6th May 2012; corrected online 8th February 2013 In the version of this Article that was originally published, the acknowledgement to M. Winey was omitted i...
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Article
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore
Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segregation are mediated by the multi-...
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Article
A tethered catalysis, two-hybrid system to identify protein-protein interactions requiring post-translational modifications
We have modified the yeast two-hybrid system to enable the detection of protein-protein interactions that require a specific post-translational modification, using the acetylation of histones and the phosphory...
