30 Result(s)
within
Tong Zhu
Medicine & Public Health
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Article
Open AccessAssociations of daytime nap** and nighttime sleep quality with depressive symptoms in older Chinese: the Guangzhou biobank cohort study
Poor sleep quality has been linked to depression in older adults, but results of the association between daytime nap** and depression remains limited and conflicting. Moreover, whether the association of day...
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Article
Obesity indicators as mediators of the association between age at menopause and blood pressure values
Having a later age at menopause is associated with having a higher blood pressure (BP) value, but the mediation pathways remain unclear. We quantitatively examined the mediation effects of various obesity indi...
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Article
Open AccessComprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer
Loss of G2-specific E3-like (G2E3) protein sensitizes tumor cells to chemotherapy. However, the role of G2E3 in breast cancer development and patient’s prognosis is unclear. Here, we explored the expression, p...
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Open AccessAssociation of alcohol use with memory decline in middle-aged and older Chinese: a longitudinal cohort study
Previous studies on associations of alcohol use with memory decline showed inconclusive results. We examined these associations using longitudinal data from the Guangzhou Biobank Cohort Study (GBCS) and explor...
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Open AccessMyocardial infarction size as an independent predictor of intramyocardial haemorrhage in acute reperfused myocardial ischaemic rats
In previous studies, haemorrhage occurred only with large infarct sizes, and studies found a moderate correlation between the extent of necrosis and haemorrhage, but the extent of infarction size in these stud...
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Article
Elevated CXCL13 in primary Sjögren’s syndrome and its correlation with disease activity: a systematic review and meta-analysis
CXCL13 levels have been reported to be elevated in primary Sjögren’s syndrome (pSS) patients. This study investigated alterations involving the CXCL13/CXCR5 axis in pSS patients and explored the correlation be...
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Open AccessHearing loss and depressive symptoms in older Chinese: whether social isolation plays a role
Existing evidence links hearing loss to depressive symptoms, with the extent of association and underlying mechanisms remaining inconclusive. We conducted a cross-sectional study to examine the association of ...
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Open AccessAssociation between spicy foods consumption and cardiovascular disease risk factors: Guangzhou Biobank Cohort Study
Evidence regarding the association of spicy foods intake with cardiovascular disease (CVD) risk factors was less clear, especially in those with diabetes. We hereby examined the association of spicy foods inta...
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Open AccessComprehensive analysis of the expression, prognostic significance, and function of FAM83 family members in breast cancer
The FAM83 family plays a key role in tumorigenesis and cancer progression. However, the role of the FAM83 family in the development of breast tumors is unclear to date. This report explores the expression, progno...
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Article
Open AccessHighly differential count of circulating and tumor infiltrating immune cells in patients with non-HCV/non-HBV hepatocellular carcinoma
Liver transplantation and liver resection are curative options for early hepatocellular carcinoma (HCC). The outcome is in part depended on the immunological response to the malignancy. In this study, we aimed...
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Open AccessFactors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey
The combination of antipsychotics is not well studied among non-psychotic major depressive disorder (MDD). This study aims to explore the antipsychotics use in this population and its associated factors.
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Open AccessLow-dose dobutamine cardiovascular magnetic resonance segmental strain study of early phase of intramyocardial hemorrhage rats
This study investigates the segmental myocardial strain of the early phase of intramyocardial hemorrhage (IMH) caused by reperfused myocardial infarction (MI) in rats by low-dose dobutamine (LDD) cardiovascula...
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Article
Pyk2 level is a novel prognostic marker for patients with esophageal squamous cell carcinoma after radical surgery
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in East Asia. Surgical resection is currently the typical treatment. However, due to the highly invasive and metastatic char...
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Article
Open AccessPhase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D1 receptor positive allosteric modulator in patients with schizophrenia
ASP4345, a novel dopamine D1 receptor positive allosteric modulator, is being evaluated for the treatment of cognitive impairment associated with schizophrenia (CIAS). This phase 1 multiple ascending-dose study (...
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Article
Open AccessPharmacokinetics of ASP4345 from Single Ascending-Dose and Multiple Ascending-Dose Phase I Studies
Cognitive impairment is a core feature of schizophrenia. While first- and second-generation antipsychotic drugs treat psychotic exacerbations, no treatment is approved for the cognitive dysfunction. We have id...
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Article
Using low-cost sensor technologies and advanced computational methods to improve dose estimations in health panel studies: results of the AIRLESS project
Air pollution epidemiology has primarily relied on fixed outdoor air quality monitoring networks and static populations.
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Article
Open AccessInvestigation of Potential Drug–Drug Interactions between Peficitinib (ASP015K) and Methotrexate in Patients with Rheumatoid Arthritis
Methotrexate is frequently used to treat rheumatoid arthritis. Peficitinib (ASP015K; Smyraf®), an oral Janus kinase inhibitor indicated for the treatment of rheumatoid arthritis, may be coadministered with methot...
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Article
Open AccessConstruction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index
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Article
Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model
To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI).
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Article
Open AccessMR extracellular volume map** and non-contrast T1ρ map** allow early detection of myocardial fibrosis in diabetic monkeys
To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.
