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Article
Open AccessConvergence analysis of approximation formulas for analytic functions via duality for potential energy minimization
We investigate the approximation formulas that were proposed by Tanaka & Sugihara (IMA J. Numer. Anal. 39(4):1957–1984, 2019), in weighted Hardy spaces, which are analytic function spaces with certain asymptot...
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Article
Open AccessMonte Carlo construction of cubature on Wiener space
In this paper, we investigate application of mathematical optimization to construction of a cubature formula on Wiener space, which is a weak approximation method of stochastic differential equations introduce...
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Article
Open AccessTherapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity
Although the exact pathogenesis of idiopathic pulmonary fibrosis (IPF) is still unknown, the transdifferentiation of fibroblasts into myofibroblasts and the production of extracellular matrix components such a...
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Article
Maximum likelihood estimation of the Fisher–Bingham distribution via efficient calculation of its normalizing constant
This paper proposes an efficient numerical integration formula to compute the normalizing constant of Fisher–Bingham distributions. This formula uses a numerical integration formula with the continuous Euler t...
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Article
Correction to: Kernel-based interpolation at approximate Fekete points
An equation in Section 2.1 has been corrected.
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Article
Kernel-based interpolation at approximate Fekete points
We construct approximate Fekete point sets for kernel-based interpolation by maximising the determinant of a kernel Gram matrix obtained via truncation of an orthonormal expansion of the kernel. Uniform error ...
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Article
High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation
Diabetes mellitus is associated with bone fragility. Although osteoblast maturation is disturbed in patients with diabetes mellitus, the involvement of high glucose (HG) in different stages of osteoblast matur...
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Construction of Approximation Formulas for Analytic Functions by Mathematical Optimization
We describe our methods developed recently to construct formulas for approximating functions and numerical integration. Our methods are developed basically for improving the with variable transformations kno...
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Article
Generation of point sets by convex optimization for interpolation in reproducing kernel Hilbert spaces
We propose algorithms to take point sets for kernel-based interpolation of functions in reproducing kernel Hilbert spaces (RKHSs) by convex optimization. We consider the case of kernels with the Mercer expansi...
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Article
Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts
Fam210a is a novel protein regulating muscle mass and strength in mice in vivo. However, detailed effects of Fam210a on the function of myoblasts as well as modulators of Fam210a are still unknown. We, thus, i...
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Article
Open AccessA2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion
The adenosine A2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of the A2B receptor and evaluated their effect on adenos...
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Article
Open AccessIdebenone has preventative and therapeutic effects on pulmonary fibrosis via preferential suppression of fibroblast activity
Alveolar epithelial injury induced by reactive oxygen species (ROS) and abnormal collagen production by activated fibroblasts (myofibroblasts) is involved in the onset and exacerbation of idiopathic pulmonary ...
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Article
Bazedoxifene Ameliorates Homocysteine-Induced Apoptosis via NADPH Oxidase-Interleukin 1β and 6 Pathway in Osteocyte-like Cells
Homocysteine (Hcy) increases oxidation and inflammation; however, the mechanism of Hcy-induced bone fragility remains unclear. Because selective estrogen modulators (SERMs) have an anti-oxidative effect, SERMs...
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Article
Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells
Previous studies suggested that advanced glycation end products (AGEs) and insulin-like growth factor-I (IGF-I) are involved in the mechanism of diabetes-induced sarcopenia. In this study, we examined effects ...
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Article
Overweight and underweight are risk factors for vertebral fractures in patients with type 2 diabetes mellitus
The aim of this cross-sectional study was to examine the association between body mass index (BMI) and the prevalence of vertebral fracture (VF) in Japanese patients with type 2 diabetes (T2DM). A total of 798...
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Article
Osteoporosis and vertebral fracture are associated with deterioration of activities of daily living and quality of life in patients with type 2 diabetes mellitus
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture. However, whether diabetes-related osteoporosis independently contributes to the deterioration of activities of daily ...
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Article
Open AccessProtective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice
Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. I...
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Article
Advanced Glycation End Product 3 (AGE3) Increases Apoptosis and the Expression of Sclerostin by Stimulating TGF-β Expression and Secretion in Osteocyte-Like MLO-Y4-A2 Cells
Advanced glycation end products (AGEs) cause bone fragility due to deterioration in bone quality. We previously reported that AGE3 induced apoptosis and inhibited differentiation via increased transforming gro...
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Article
Open AccessPreventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play importan...
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Article
Open AccessAminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome
Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound library of drugs clinically used for ...
