13 Result(s)
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Article
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein–nucleic acid complexes in cryogenic electron microscopy (cryo-EM) ...
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Article
Open AccessHuman DNA-dependent protein kinase activation mechanism
DNA-dependent protein kinase (DNA-PK), a multicomponent complex including the DNA-PK catalytic subunit and Ku70/80 heterodimer together with DNA, is central to human DNA damage response and repair. Using a DNA...
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Open AccessMycobacterium abscessus pathogenesis identified by phenogenomic analyses
The medical and scientific response to emerging and established pathogens is often severely hampered by ignorance of the genetic determinants of virulence, drug resistance and clinical outcomes that could be u...
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Article
Dimers of DNA-PK create a stage for DNA double-strand break repair
DNA double-strand breaks are the most dangerous type of DNA damage and, if not repaired correctly, can lead to cancer. In humans, Ku70/80 recognizes DNA broken ends and recruits the DNA-dependent protein kinas...
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Article
Dissection of DNA double-strand-break repair using novel single-molecule forceps
Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ) requires multiple proteins to recognize and bind DNA ends, process them for compatibility, and ligate them together. We constructed...
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Open AccessOn the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture
The hydrogen bond patterns between mainchain atoms in protein structures not only give rise to regular secondary structures but also satisfy mainchain hydrogen bond potential. However, not all mainchain atoms ...
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Structural and functional constraints in the evolution of protein families
The process of protein evolution is balanced between Darwinian selection for functionally advantageous mutations and neutral evolution, in which acceptance of ...
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Article
Is one solution good enough?
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Article
Crystal structure of an Xrcc4–DNA ligase IV complex
A complex of two proteins, Xrcc4 and DNA ligase IV, plays a fundamental role in DNA non-homologous end joining (NHEJ), a cellular function required for double-strand break repair and V(D)J recombination. Here ...
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Article
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding
Although ligand-induced receptor dimerization is a common prerequisite for receptor activation, the mode by which different growth factors bind their receptors and cause them to dimerize varies c...
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Article
Leaving the structured world of Oxford
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Article
Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing
The structure of L-aspartate-α-decarboxylase from E. coli has been determined at 2.2 Å resolution. The enzyme is a tetramer with pseudofour-fold rotational symmetry. The subunits are six-stranded β-barrels capped...
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Article
Metalloproteinase super–families and drug design
The common topology of the matrix metalloproteinase family, and details of the structures of individual members, will intensify efforts to develop drugs for diseases such as arthritis and cancer.
