The common topology of the matrix metalloproteinase family, and details of the structures of individual members, will intensify efforts to develop drugs for diseases such as arthritis and cancer.
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References
Borkakoti et al., Nature struct. Biol. 1, 106–110 (1994).
Gooley et al., Nature struct. Biol. 1, 111–118 (1994).
Stams, T., Spurlino, L., Wahl, R.C., Ho, T.F., Qoronfleth, M.W., Banks, T.M. & Rubin, B. Nature struct. Biol. 1, 119–123 (1994).
Bode, W., Reinemer, P., Huber, R., Kleine, T., Schneierer, S. and Tschesche EMBO J. (in the press).
Lovejoy, B. et al., Science (in the press).
Docherty, A.J.P. et al., Trends Biology 10, 200–207 (1992).
Basset, P. et al., Nature 348, 699–704 (1990).
Bode, W. et al., Nature 358, 164–167 (1992).
Gomis-Ruth, F.X., Kress, L.F. and Bode, W. EMBO J. 12, 4151–4157 (1993).
Baumann, U., Wu, S., Flaherty, K.M. & McKay, D.B. EMBO J. In Press, (1994).
Bode, W., Gomis-Ruth, F.X. & Stocker, W. FEBS Lett. 331, 134–140 (1993).
Johnson, M.J., Overington, J. & Blundell, T.L. J. molec. Biol. 231, 735–752 (1993).
Grams, F. et al., FEBS Lett. 335, 76–80 (1993).
Matthews, B.W. et al., Nature new Biol. 238, 37–41 (1972)10.
Pauptit, R.A. et al. J. molec. Biol. 199, 525–537 (1988).
Thayer, M.M., Flaherty, K.M. & Mackay, D.B. J. biol. Chem. 266, 2864–2871 (1991).
Schechter, I. and Berger, A. Biochem. Biophys. Res. Commun. 27, 157–162 (1967).
Johnson, W.H., Roberts, N.A. & Borkakoti, N.J. Enzyme Inhibition 2, 1–22 (1987).
Weaver, L.H., Kester, W.R. and Matthews, B.W. J. molec. Biol. 114, 119–132 (1977).
Blundell, T.L. and Johnson, M.J. Prot. Sci. 2, 877–883 (1993).
Spurlino et al. Proteins (in the press).
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Blundell, T. Metalloproteinase super–families and drug design. Nat Struct Mol Biol 1, 73–75 (1994). https://doi.org/10.1038/nsb0294-73
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DOI: https://doi.org/10.1038/nsb0294-73
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