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  1. No Access

    Article

    Regulation of arsenic methylation: identification of the transcriptional region of the human AS3MT gene

    The human enzyme As(III) S-adenosylmethionine methyltransferase (AS3MT) catalyzes arsenic biotransformations and is considered to contribute to arsenic-related diseases. AS3MT is expressed in various tissues a...

    Kunie Yoshinaga-Sakurai, Toby G. Rossman, Barry P. Rosen in Cell Biology and Toxicology (2022)

  2. No Access

    Article

    Variability in sensitivity to arsenite does not correlate with arsenic accumulation rate in normal human lymphoblasts

    Arsenic is a common environmental contaminant of our air, water and food, but not every individual who drinks arsenic-contaminated water shows clinical signs of toxicity. Large inter-individual variations are ...

    ** Li, Ahmed N. Uddin, Zijuan Liu… in Molecular and Cellular Biochemistry (2004)

  3. No Access

    Article

    fau and its ubiquitin-like domain (FUBI) transforms human osteogenic sarcoma (HOS) cells to anchorage-independence

    Arsenite is the most likely carcinogenic form of arsenic in the environment. Previously, expression cloning for cDNAs whose overexpression confers arsenite-resistance in Chinese hamster V79 cells identified tw...

    Toby G Rossman, Melissa A Visalli, Elena V Komissarova in Oncogene (2003)

  4. No Access

    Chapter

    Effects of metallothionein expression on development of drug resistance

    Metallothioneins (MTs) are low molecular weight metal-binding proteins with about 30% cysteine content [1]. MTs have been postulated to function in the protection against heavy metals, scavenging of free radic...

    Toby G. Rossman, Ekaterina I. Goncharova in Metallothionein IV (1999)

  5. No Access

    Article

    Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells

    Solar ultraviolet radiation has been associated with the induction of skin cancer. Recent studies have indicated that near-ultraviolet, especially UVB, is mutagenic. Exposure to trivalent inorganic arsenic com...

    Jih-Heng Li, Toby G. Rossman in Biology of Metals (1991)

  6. No Access

    Chapter

    DNA Damage by Mercury Compounds: An Overview

    HgCl2-induced DNA damage has many similarities to those caused by X-rays; however, the single strand breaks induced by HgCl2 are not readily repaired, in contrast to those induced by X-rays. HgCl2 has also been s...

    Max Costa, Nelwyn T. Christie, Orazio Cantoni… in Advances in Mercury Toxicology (1991)

  7. No Access

    Article

    Foreword

    Toby G. Rossman, Max Costa in Biological Trace Element Research (1989)

  8. No Access

    Chapter

    Use of the Microscreen Assay for Airborne Particulate Organic Matter

    The value of short-term in vitro assays to screen for potential human mutagens and carcinogens is well established. The most extensively validated short-term assay is the Ames test (Ames etal., 1975). This assay ...

    Toby G. Rossman, LeRoy W. Meyer… in Short-Term Bioassays in the Analysis of Co… (1985)

  9. No Access

    Article

    Differential Effects of Actinomycin D and Puromycin on the Release of Interferon induced by Double Stranded RNA

    THE induction of interferon production with synthetic double stranded RNA1 is suppressed by actinomycin D2,3. Finkelstein et al.4, however, reported that considerably higher concentrations of actinomycin D were r...

    JAN VILČEK, TOBY G. ROSSMAN, FERMINA VARACALLI in Nature (1969)