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Article
Open AccessPerinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
The contribution of γδ T cells to immune responses is associated with rapid secretion of interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T cells that express CD8αβ hete...
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Article
Open AccessJAK-STAT signaling maintains homeostasis in T cells and macrophages
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we d...
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Article
Open AccessCorrection: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessSTAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia
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Article
Open AccessStructural and functional consequences of the STAT5BN642H driver mutation
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patie...
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Article
Open AccessDependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating ...
