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Quantifying the evolutionary dynamics of language

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  1. Article

    Open Access

    Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

    Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activ...

    Alexander Roberts, Lindsay Bentley, Tina Tang, Fay Stewart in Scientific Reports (2021)

  2. Article

    Open Access

    Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

    In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lip...

    Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe in Scientific Reports (2017)