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  1. Article

    Open Access

    Bacterial genome-wide association study substantiates papGII of Escherichia coli as a major risk factor for urosepsis

    Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, often caused by uropathogenic Escherichia coli. Multiple bacterial virulence factors or patient characteristics have been ...

    Aline Cuénod, Jessica Agnetti, Helena M. B. Seth-Smith, Tim Roloff… in Genome Medicine (2023)

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  2. No Access

    Protocol

    Biosynthesis of Glycoconjugate Virus-like Particles (VLPs)

    The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures—polysaccharides, glycolipids, and glycoproteins. To raise a long-lasting and effective immune response against...

    Kathryn K. Oi, Tom A. Kloter, Timothy G. Keys in Vaccine Delivery Technology (2021)

  3. Article

    Open Access

    Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies

    Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains limited. Established bacterial glycoengineering platform...

    Hanne L. P. Tytgat, Chia-wei Lin, Mikail D. Levasseur… in Nature Communications (2019)

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  4. No Access

    Article

    Think small – Methoden zur in vitro-Evolution von Polymerasen

    Polysaccharides are abundant extracellular matrix components and ideal materials for next-generation bioprostheses. Because the chain length critically impacts polymer properties, biotechnological production r...

    Timothy G. Keys, Rita Gerardy-Schahn in BIOspektrum (2015)

  5. No Access

    Article

    Engineering the product profile of a polysialyltransferase

    Functional assessments and applications of polysaccharides are hampered by broad product distributions. Neutral drift libraries now identify specific amino acids and binding sites that determine product outcom...

    Timothy G Keys, Hazel L S Fuchs, Jörg Ehrit, Jürgen Alves… in Nature Chemical Biology (2014)