SialoGlyco Chemistry and Biology I
Biosynthesis, structural diversity and sialoglycopathologies
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28 Result(s)
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Rita Gerardy-Schahn
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Open AccessA multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule
Bacterial capsules have critical roles in host-pathogen interactions. They provide a protective envelope against host recognition, leading to immune evasion and bacterial survival. Here we define the capsule b...
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Open AccessMolecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy
Virus-neutralizing antibodies are a severe obstacle in oncolytic virotherapy. Here, we present a strategy to convert this unfavorable immune response into an anticancer immunotherapy via molecular retargeting....
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Open AccessIntrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells
Polysialic acid (polySia) is a carbohydrate modification of the neural cell adhesion molecule (NCAM), which is implicated in neural differentiation and plays an important role in tumor development and metastas...
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Open AccessAn efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate
Invasive meningococcal disease (IMD) is a global health problem and vaccination has proven the most effective way of disease control. Neisseria meningitidis serogroup X (NmX) is an emerging threat in the African ...
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Environmental enrichment rescues memory in mice deficient for the polysialytransferase ST8SiaIV
The neural cell adhesion molecule NCAM and its association with the polysialic acid (PSA) are believed to contribute to brain structural plasticity that underlies memory formation. Indeed, the attachment of lo...
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Think small – Methoden zur in vitro-Evolution von Polymerasen
Polysaccharides are abundant extracellular matrix components and ideal materials for next-generation bioprostheses. Because the chain length critically impacts polymer properties, biotechnological production r...
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Open AccessA Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism
In mammals, UDP-glucose pyrophosphorylase (UGP) is the only enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc), a metabolite located at the intersection of virtually all metabo...
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Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice
Posttranslational modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is crucial for nervous system development and brain plasticity. PolySia attachment is catalyzed by the po...
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Engineering the product profile of a polysialyltransferase
Functional assessments and applications of polysaccharides are hampered by broad product distributions. Neutral drift libraries now identify specific amino acids and binding sites that determine product outcom...
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Soluble polysialylated NCAM: a novel player of the innate immune system in the lung
Posttranslational modification of the neural cell adhesion molecule (NCAM) by polysialic acid (polySia) is well studied in the nervous system and described as a dynamic modulator of plastic processes like prec...
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Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2
The glycan polysialic acid is well-known as a unique posttranslational modification of the neural cell adhesion molecule NCAM. Despite remarkable acceptor specificity, however, a few other proteins can be targ...
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Polysialinsäure — ein Zucker reguliert die Hirnentwicklung
Modification with polysialic acid controls functions of the neural cell adhesion molecule NCAM during ontogenic processes. This cooperation between a protein and its posttranslational modification provides an ...
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"Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein
The glycolipid specific Drosophila melanogaster β1,4-N-acetylgalactosaminyltransferase B (β4GalNAcTB) depends on a zinc finger DHHC protein family member named GalNAcTB pilot (GABPI) for activity and translocatio...
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Open AccessIncorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2
Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream. The C-type lectin DC-SIGN ...
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Crystal structure of an intramolecular chaperone mediating triple–β-helix folding
Some viral proteins involved in interaction with the host cell surface adopt a very rigid and stable triple–β-helix fold. In order to attain this complex fold, these proteins contain an intramolecular chaperon...
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Polysialylation of NCAM
A unique feature of the neural cell adhesion molecule NCAM is that it can be decorated with polysialic acid, a large negatively charged and highly hydrated glycan, which acts as a key regulator of NCAM-mediate...
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Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycosphingolipid biosynthesis
Drosophila melanogaster has two β4-N-acetylgalactosaminyltransferases, β4GalNAcTA and β4GalNAcTB, that are able to catalyse the formation of lacdiNAc (GalNAcβ,4GlcNAc). LacdiNAc is found ...
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A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase
CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and CTP to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP i . Saturation Transfer Diffe...
