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  1. Article

    Open Access

    Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies

    Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains limited. Established bacterial glycoengineering platform...

    Hanne L. P. Tytgat, Chia-wei Lin, Mikail D. Levasseur… in Nature Communications (2019)

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  2. Article

    Open Access

    Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

    The protease BACE1 (beta-site APP cleaving enzyme) is a major drug target in Alzheimer’s disease. However, BACE1 therapeutic inhibition may cause unwanted adverse effects due to its additional functions in the...

    Martina Pigoni, Johanna Wanngren, Peer-Hendrik Kuhn… in Molecular Neurodegeneration (2016)

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