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Author Correction: Julia for biologists
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Julia for biologists
Major computational challenges exist in relation to the collection, curation, processing and analysis of large genomic and imaging datasets, as well as the simulation of larger and more realistic models in sys...
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Open AccessFast objective coupled planar illumination microscopy
Among optical imaging techniques light sheet fluorescence microscopy is one of the most attractive for capturing high-speed biological dynamics unfolding in three dimensions. The technique is potentially milli...
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Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning
In this Letter, ‘≥’ should be ‘≤’ in the sentence: “Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)”. This error has been corrected online.
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Sensory experience remodels genome architecture in neural circuit to drive motor learning
Neuronal-activity-dependent transcription couples sensory experience to adaptive responses of the brain including learning and memory. Mechanisms of activity-dependent gene expression including alterations of ...
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Olfactory bulb connectomics: a silver lining
In high-throughput electron microscopy, a simple method to reduce artifacts helps reveal the architecture of circuits in the develo** zebrafish olfactory bulb.
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Scenting Waldo: analyzing olfactory scenes
Olfaction has often been described as a 'synthetic' sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes ...
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High-Energy Collision-Induced Dissociation by MALDI TOF/TOF Causes Charge-Remote Fragmentation of Steroid Sulfates
A method for structural elucidation of biomolecules dating to the 1980s utilized high-energy collisions (~10 keV, laboratory frame) that induced charge-remote fragmentations (CRF), a class of fragmentations pa...
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Functional organization of glomerular maps in the mouse accessory olfactory bulb
Unlike that of its main counterpart, the functional organization of the accessory olfactory bulb, important for detecting socially relevant odors, remains to be detailed. Here the authors map out Ca2+ signals fro...
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Mass Spectrometry Combinations for Structural Characterization of Sulfated-Steroid Metabolites
Steroid conjugates, which often occur as metabolites, are challenging to characterize. One application is female-mouse urine, where steroid conjugates serve as important ligands for the pheromone-sensing neuro...
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Whole-Mount Imaging of Responses in Mouse Vomeronasal Neurons
Imaging permits the visualization of neural activity from the whole-mount vomeronasal sensory epithelium with single-cell resolution. The preparation preserves an intact tissue environment, enabling the robust...
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Electrical Recordings from the Accessory Olfactory Bulb in VNO-AOB Ex Vivo Preparations
Electrical recordings from individual accessory olfactory bulb neurons allow exploration of the functional properties of this important pheromonal processing circuit. Several approaches to performing such reco...
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Reward alters specific connections
How does the brain couple a fleeting sensory input to a delayed reward during learning? A study in locusts shows that coincident firing of neurons can 'mark' a neuronal connection for later modulation. See Articl...
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“Yes! We're all individuals!”: redundancy in neuronal circuits
In the mouse olfactory bulb, cells with common input respond to odors with similar firing rates but with different timing. This suggests that such 'sister' cells make independent and unique connections with lo...
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Representation and transformation of sensory information in the mouse accessory olfactory system
In mice, social odors activate vomeronasal sensory neurons (VSNs); a large percentage of VSNs detect sulfated steroids. Here, the authors find that information about these molecules is conveyed through just a ...
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Pavlov's moth: olfactory learning and spike timing–dependent plasticity
Spike-timing dependent plasticity is a favored synaptic mechanism for learning. However, a surprising new study by Ito and colleagues in the insect mushroom body suggests that it cannot account for a paradigma...
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Olfactory coding: sniffing out signals
A report in Nature describes a physiological screen used to identify a previously unknown chemical signal in mouse urine. The chemical's selective response in the olfactory bulb raises interesting questions for h...
