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Article
Open AccessJAK-STAT signaling maintains homeostasis in T cells and macrophages
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we d...
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Article
Open AccessVγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes
Intracellular bacteria produce antigens, which serve as potent activators of γδ T cells. Phosphoantigens are presented via a complex of butyrophilins (BTN) to signal infection to human Vγ9+Vδ2+ T cells. Here, ...
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Article
Plasma apolipoprotein M predicts overall survival in metastatic breast cancer patients
Apolipoprotein M (APOM) is a plasma apolipoprotein closely involved with lipid metabolism and inflammation. In vitro studies suggest that APOM may also have a tumor-suppressive role in breast cancer. In the pr...
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Article
Open AccessThe Oncology Biomarker Discovery framework reveals cetuximab and bevacizumab response patterns in metastatic colorectal cancer
Precision medicine has revolutionised cancer treatments; however, actionable biomarkers remain scarce. To address this, we develop the Oncology Biomarker Discovery (OncoBird) framework for analysing the molecu...
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Article
Cell-free circulating RAS mutation concentrations significantly impact the survival of metastatic colorectal cancer patients
RAS mutations are predictors of an adverse outcome in EGFR-targeted therapies and have been proposed as prognostic biomarkers of survival in metastatic colorectal cancer (mCRC). The analysis of circulating tum...
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Article
Open AccessThird International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)
The heterogeneous group of B3 lesions in the breast harbors lesions with different malignant potential and progression risk. As several studies about B3 lesions have been published since the last Consensus in ...
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Article
Open AccessThe INFINITY study protocol: a retrospective cohort study on decision making and clinical impact of biomarker-driven precision oncology in routine clinical practice
Precision oncology, defined as treatment of patients with targeted therapies matched to specific molecular alterations, has entered routine clinical practice. Particularly in patients with advanced cancer or h...
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Article
Open AccessPRECYCLE: multicenter, randomized phase IV intergroup trial to evaluate the impact of eHealth-based patient-reported outcome (PRO) assessment on quality of life in patients with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer treated with palbociclib and an aromatase inhibitor or palbociclib and fulvestrant
Efficacy and quality of life (QoL) are key criteria for therapy selection in metastatic breast cancer (MBC). In hormone receptor positive (HR +) human epidermal growth factor receptor 2 negative (HER2 −) MBC, ...
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Article
Personalisierte Medizin – von der Translation zur Klinik
Mutationsanalysen spielen eine zunehmende Rolle bei der Therapie des fortgeschrittenen Mammakarzinoms.
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Article
Open AccessExperimental Validation of a Structure-Borne Sound Model of a Direct Drive Wind Turbine Generator
In this paper the methodology and results of the validation of a multi-physical system model of a direct drive wind turbine are presented. The analyzed model serves the purpose of examining the structure borne...
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Article
Open AccessSimulation methodology for the identification of critical operating conditions of planetary journal bearings in wind turbines
The usage of journal bearings as planetary bearings in wind turbines instead of roller bearings has become more common in recent years. Their usage is advantageous, due to smaller installation space needed com...
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Article
Open AccessStandard diametric versus volumetric early tumor shrinkage as a predictor of survival in metastatic colorectal cancer: subgroup findings of the randomized, open-label phase III trial FIRE-3 / AIO KRK-0306
Early tumor shrinkage (ETS) quantifies the objective response at the first assessment during systemic treatment. In metastatic colorectal cancer (mCRC), ETS gains relevance as an early available surrogate for ...
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Chapter and Conference Paper
Towards Scenario-Based Safety Validation for Autonomous Trains with Deep Generative Models
Modern AI techniques open up ever-increasing possibilities for autonomous vehicles, but how to appropriately verify the reliability of such systems remains unclear. A common approach is to conduct safety valid...
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Chapter and Conference Paper
The Thousand Faces of Explainable AI Along the Machine Learning Life Cycle: Industrial Reality and Current State of Research
In this paper, we investigate the practical relevance of explainable artificial intelligence (XAI) with a special focus on the producing industries and relate them to the current state of academic XAI research...
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Article
Open AccessEfficacy of FOLFIRI plus cetuximab vs FOLFIRI plus bevacizumab in 1st-line treatment of older patients with RAS wild-type metastatic colorectal cancer: an analysis of the randomised trial FIRE-3
The evidence on the efficacy of anticancer therapy is limited in older patients with metastatic colorectal cancer (mCRC). This retrospective analysis of phase III FIRE-3 trial assesses the efficacy of FOLFIRI ...
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Article
Therapie des metastasierten Mammakarzinoms
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Article
Breast carcinomas of low malignant potential
Some breast carcinomas have a very low likelihood of metastasis to regional lymph nodes and distant sites and may be considered carcinomas of low malignant potential. In this article, we review the clinical, p...
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Article
Open AccessPhase II study of metronomic treatment with daily oral vinorelbine as first-line chemotherapy in patients with advanced/metastatic HR+/HER2− breast cancer resistant to endocrine therapy: VinoMetro—AGO-B-046
Metronomic chemotherapy (MCT) is an increasingly used treatment option in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) advanced/metastatic breast cancer (MBC) after...
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Article
Open AccessThe AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity
Dendritic cell (DC) development is orchestrated by lineage-determining transcription factors (TFs). Although, members of the activator-protein-1 (AP-1) family, including Batf3, have been implicated in conventi...
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Article
Open AccessSignificant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients
Mutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course of metastatic breast cancer (MBC). In the present study we used targeted next generation sequencing o...
