21 Result(s)

Article

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumat...

Eva Schrezenmeier, Thomas Dörner in Nature Reviews Rheumatology (2020)

Article

Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE

Article

Biosimilars in rheumatology: current perspectives and lessons learnt

Article

Emerging cell and cytokine targets in rheumatoid arthritis

Article

Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis

The association between coagulation and the immune system has been increasingly recognised to have a role in the development of inflammatory rheumatic diseases. The fact that the risk of venous thromboembolism...

Berthold Hoppe, Thomas Dörner in Nature Reviews Rheumatology (2012)

Article

Deciphering the role of NETs and networks in SLE

From neutrophil extracellular traps to genetic networks that underlie the disease and new targeted therapies, important advances in 2011 improve our understanding of the pathogenesis of systemic lupus erythema...

Thomas Dörner in Nature Reviews Rheumatology (2012)

Article

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

Immunological memory is a cornerstone of the defence against pathogens, ensuring that repeated exposures to an antigen produce faster, more robust responses. Might chronic autoimmune diseases likewise owe thei...

Falk Hiepe, Thomas Dörner, Anja E. Hauser, Bimba F. Hoyer… in Nature Reviews Rheumatology (2011)

Article

B-cell-directed therapies for autoimmune disease

B-cell-directed therapies for autoimmune diseases have been the focus of extensive research during the past few years. In this Review, the authors discuss therapies that directly and indirectly target B cells....

Thomas Dörner, Andreas Radbruch, Gerd R. Burmester in Nature Reviews Rheumatology (2009)

Article

Is there a 'window of opportunity' for intervention to reduce risk of coronary artery disease in SLE?

Patients with systemic lupus erythematosus (SLE) have a substantially enhanced risk for cardiovascular complications, especially coronary artery disease (CAD). Evidence from a recent study by Urowitz et al. indi...

Berthold Hoppe, Thomas Dörner in Nature Clinical Practice Rheumatology (2008)

Article

B-cell lymphoproliferation in chronic inflammatory rheumatic diseases

Patients with chronic inflammatory rheumatic diseases, such as primary Sjögren's syndrome, systemic lupus erhythematosus and rheumatoid arthritis, are at higher risk of develo** B-cell non-Hodgkin lymphomas ...

Arne Hansen, Peter E Lipsky, Thomas Dörner in Nature Clinical Practice Rheumatology (2007)

Article

Implant-related inflammatory arthritis

Background A 54-year-old woman presented with myalgia and arthralgia predominantly in the knees and small joints of the hands and feet with morning stiffness lasting for at least 2 h. The patient had received a w...

Thomas Dörner, Judith Haas, Christoph Loddenkemper… in Nature Clinical Practice Rheumatology (2006)

Article

Treatment of rheumatoid arthritis in the 21st century: targeting B-lymphocytes

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent inflammation of synovial tissue. Although the initiating event of RA is still unknown, recent research has demonstrated t...

Hans-Peter Brezinschek, Kerstin Brickmann… in Wiener Medizinische Wochenschrift (2006)

Article

B-Zell-Depletion in der Therapie der rheumatoiden Arthritis

In der Behandlung rheumatischer Erkrankungen kommt der selektiven Immunblockade eine zunehmende Bedeutung zu. Die Anti-TNFα-Therapie überzeugt dabei durch eine hohe Effektivität und Erfolge in bisher therapi...

Dr. Eugen Feist, Gerd-R. Burmester, Thomas Dörner in Zeitschrift für Rheumatologie (2003)

Article

Zytometrische Analysen bei systemischen Autoimmunerkrankungen

Im Rahmen von rheumatisch-entzündlichen Erkrankungen, insbesondere den Kollagenosen sind Autoantikörper von diagnostischer und auch ätiopathogenetischer Relevanz. Über die Zellen, die diese Autoantikörper pro...

Thomas Dörner, Marcus Odendahl, Andreas Radbruch in Zeitschrift für Rheumatologie (2002)