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Article
Open AccessRecruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow
Bone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation...
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Article
Antikoagulation und Thrombozytenfunktionshemmung
Viele Augenerkrankungen, die eine operative Intervention erfordern, sind Erkrankungen des älteren Menschen. Daher bestehen häufig internistische Komorbiditäten. In deren Behandlung spielt in vielen Fällen die ...
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Article
Open AccessTranscriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome
Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compa...
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Article
Open AccessPraktikable Sjögren-Diagnostik bei interstitieller Lungenerkrankung – ein Diskussionsbeitrag
Das Sjögren-Syndrom (SjS) stellt eine mögliche autoimmune Ursache einer interstitiellen Lungenerkrankung dar. Die Abklärung in Richtung SjS ist aber im Vergleich zu anderen systemischen Autoimmunerkrankungen b...
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Chapter
Sjögren-Syndrom
Das Sjögren-Syndrom stellt eine mögliche Manifestation des Lupus dar, die durch Entzündung in den exkretorischen Drüsen gekennzeichnet ist. Abgegrenzt werden muss es allerdings von einem primären Sjögren-Syndr...
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Article
B-Lymphozyten und Plasmazellen als Treiber rheumatischer Erkrankungen
Verschiedene Arbeitsgruppen am Deutschen Rheuma-Forschungszentrum Berlin haben in enger Zusammenarbeit mit der Medizinischen Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie an der Charité wichti...
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Article
Open AccessEarly and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies
Six to 19% of critically ill COVID-19 patients display circulating auto-antibodies against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for early identification of IFN-AAB...
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Article
Open AccessA Narrative Literature Review Comparing the Key Features of Musculoskeletal Involvement in Rheumatoid Arthritis and Systemic Lupus Erythematosus
Although the clinical approach to the management of musculoskeletal manifestations in systemic lupus erythematosus (SLE) is often similar to that of rheumatoid arthritis (RA), there are distinct differences in...
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Article
Open AccessBaricitinib decreases anti-dsDNA in patients with systemic lupus erythematosus: results from a phase II double-blind, randomized, placebo-controlled trial
Patients with systemic lupus erythematosus (SLE) have substantial unmet medical need. Baricitinib is a Janus kinase (JAK)1 and 2 inhibitor that was shown to have therapeutic benefit in patients with SLE in a p...
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Article
Antikoagulation und Thrombozytenfunktionshemmung
Viele Augenerkrankungen, die eine operative Intervention erfordern, sind Erkrankungen des älteren Menschen. Daher bestehen häufig internistische Komorbiditäten. In deren Behandlung spielt in vielen Fällen die ...
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Article
Open AccessViscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation re...
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Article
Therapeutic Recommendations for the Management of Older Adult Patients with Sjögren’s Syndrome
Primary Sjögren’s syndrome (SjS) is a systemic autoimmune disease most commonly diagnosed in middle-aged women. Although the disease can occur at all ages, it is diagnosed between 30 and 60 years of age in two...
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Article
Open AccessSARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself
The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immu...
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Article
Toll-like receptor signalling in B cells during systemic lupus erythematosus
B lymphocytes have a central role in autoimmune diseases, which are often defined by specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease associated with B cell hyperacti...
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Article
Open AccessThromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis
There is emerging evidence for enhanced blood coagulation in coronavirus 2019 (COVID-19) patients, with thromboembolic complications contributing to morbidity and mortality. The mechanisms underlying this prot...
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Article
Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumat...
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Article
Open AccessSwitching Between Reference Biologics and Biosimilars for the Treatment of Rheumatology, Gastroenterology, and Dermatology Inflammatory Conditions: Considerations for the Clinician
Biosimilars of the reference biologic therapeutics infliximab, etanercept, adalimumab, and rituximab are entering the market. Clinical and real-world data on the effects of reference → biosimilar switching are...
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Article
Beyond pan-B-cell-directed therapy — new avenues and insights into the pathogenesis of SLE
Pan-B-cell-directed agents show only modest evidence of clinical benefit in systemic lupus erythematosus (SLE), despite the crucial role of B-lineage cells in ...
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Article
Engagement of CD22 on B cells with the monoclonal antibody epratuzumab stimulates the phosphorylation of upstream inhibitory signals of the B cell receptor
The binding of antigen to the B cell receptor (BCR) results in a cascade of signalling events that ultimately drive B cell activation. Uncontrolled B cell activation is regulated by negative feedback loops tha...
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Article
Biosimilars in rheumatology: current perspectives and lessons learnt
Biosimilars are biopharmaceuticals that have been assessed by regulatory agencies to have efficacy and safety similar to their reference products and are expec...
