12 Result(s)
within
Theodor Günther
English
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Article
In vitro evidence for a Donnan distribution of Mg 2+ and Ca2+ by chondroitin sulphate in cartilage
Fluoroquinolones are known for their ability to form chelate complexes with magnesium. Cartilage lesions observed in juvenile animals after quinolone treatment very probably are a consequence of the lack of f...
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Article
Effects of magnesium and iron on lipid peroxidation in cultured hepatocytes
In primary cultures of rat hepatocytes, the effects of extracellular Mg2+ and Fe on lipid peroxidation (LPO) as measured by means of malondialdehyde (MDA) formation were investigated.
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Article
Lipid peroxidation in mitochondria and microsomes from adult and fetal rat tissues
Pregnant female Wistar rats that received a control (100 ppm Zn) or a Zn-deficient diet (1.5 ppm Zn) from d 0 to 21, or nonpregnant normally fed female rats without or with five daily oral doses of 300 mg/kg s...
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Article
Induction of hepatic metallothionein by salicylate in adult rats
Application of salicylate increased the concentration of metallothionein (MT) in liver of pregnant rats as well as of adult male rats, whereas in fetal liver, MT was reduced by salicylate. Induction of MT synt...
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Article
Maternal and fetal iron accumulation in Zn-deficient and salicylate-treated rats
Nonhemoglobin Fe (non Hb−Fe) content in fetal serum and liver is much higher than in maternal serum and liver. After feeding a Zn-deficient diet to pregnant rats from d 0 to 21, non Hb−Fe content in maternal a...
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Article
Effects of salicylate and zinc deficiency on the serum concentrations of magnesium, calcium, and parathyroid hormone
Oral application of 700 mg/kg salicylic acid to pregnant and nonpregnant female rats caused an increase of serum Mg2+ and a decrease of serum Ca2+ concentration. The salicylate effect was drastically enhanced by ...
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Article
Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency
In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet.
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Chapter
Effects of Zn-Deficiency and Valproate on Isometallothioneins in Fetal Rat Liver
During fetal development, the content of Zn-metallothionein (Zn-MT) in liver increases, reaching a maximum at birth1. By either feeding pregnant rats a Zn-deficient diet or treatig them with valproate, Zn-MT cont...
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Chapter
Perinatal Development of Superoxide Dismutase in Rat Liver and Kidney
Superoxide dismutase (SOD) (EC 1.15.1.1.) catalyses the dismutation of the superoxide radical anion ( \( {\text{O}}_2^{\overline \bullet } \) ...
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Article
Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets
Pregnant Wistar rats fed control and Zn-deficient diets received daily oral doses of 0, 100, and 300 mg/kg sodium valproate from d 16 to 20 of gestation. Only the highest valproate doses induced a small reduct...
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Article
Development of fetal mineral and trace element metabolism in rats with normal as well as magnesium- and zinc-deficient diets
At d 17 of gestation, the concentrations of K, Mg, Mn, and Zn in fetal rat serum, measured by flame photometry and atomic absorption spectrophotometry, were higher than in maternal serum and declined thereafte...
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Article
Effect of salicylate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets
Pregnant rats fed normal and Zn-deficient diets were treated with oral daily doses of 100 and 300 mg/kg salicylic acid from d 16–20 of gestation. This treatment caused a dose-dependent reduction in fetal body ...
