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Effects of salicylate and zinc deficiency on the serum concentrations of magnesium, calcium, and parathyroid hormone

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Abstract

Oral application of 700 mg/kg salicylic acid to pregnant and nonpregnant female rats caused an increase of serum Mg2+ and a decrease of serum Ca2+ concentration. The salicylate effect was drastically enhanced by Zn deficiency. The increase in serum Mg2+ is probably caused by the nephrotoxicity of salicylate. The decrease of serum Ca2+ concentration is combined with an increase of parathyroid hormone concentration in serum. Probably, salicylate and Zn deficiency inhibit Ca2+ mobilization by parathyroid hormone in bone.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D-1000, Berlin 33, FRG

    Theodor Günther, Vera Höllriegl & Jürgen Vormann

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  1. Theodor Günther
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  2. Vera Höllriegl
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  3. Jürgen Vormann
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Günther, T., Höllriegl, V. & Vormann, J. Effects of salicylate and zinc deficiency on the serum concentrations of magnesium, calcium, and parathyroid hormone. Biol Trace Elem Res 16, 129–135 (1988). https://doi.org/10.1007/BF02797097

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  • DOI: https://doi.org/10.1007/BF02797097

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