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Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets

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Abstract

Pregnant Wistar rats fed control and Zn-deficient diets received daily oral doses of 0, 100, and 300 mg/kg sodium valproate from d 16 to 20 of gestation. Only the highest valproate doses induced a small reduction in fetal body weight in the normally fed group. Zinc deficiency caused a drastic reduction in maternal and only a small reduction in fetal serum Zn concentrations. Valproate treatment had no effect on maternal and fetal serum Zn concentrations.

Valproate reduced fetal liver Zn content only in the normally fed group. The reduction of liver Zn content resulted from the reduction of Zn-metallothionein. Valproate did not affect total Zn and Zn-metallothionein in kidneys. Three percent of the Zn-deficient fetuses developed hydronephrosis and hydrops. Valproate treatment drastically enhanced the occurrence of fetal hydronephrosis and hydrops. Valproate induced fetal liver necroses, independent of Zn nutrition.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biochemistry, Free University of Berlin, Arnimallee 22, D-1000, Berlin 33, FRG

    Jürgen Vormann, Vera Höllriegl & Theodor Günther

  2. Institute of Toxicology and Prenatal Pharmacology, Free University of Berlin, Garystr. 5, D-1000, Berlin 33, FRG

    Hans-Joachim Merker

Authors
  1. Jürgen Vormann
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  2. Vera Höllriegl
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  3. Hans-Joachim Merker
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  4. Theodor Günther
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Vormann, J., Höllriegl, V., Merker, HJ. et al. Effect of valproate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets. Biol Trace Elem Res 10, 25–35 (1986). https://doi.org/10.1007/BF02795316

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  • DOI: https://doi.org/10.1007/BF02795316

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