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Article
Open AccessEndothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts
Alveologenesis is a spatially coordinated morphogenetic event, during which alveolar myofibroblasts surround the terminal sacs constructed by epithelial cells and endothelial cells (ECs), then contract to form...
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Article
Open AccessAn analysis modality for vascular structures combining tissue-clearing technology and topological data analysis
The blood and lymphatic vasculature networks are not yet fully understood even in mouse because of the inherent limitations of imaging systems and quantification methods. This study aims to evaluate the useful...
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Article
Open AccessTransforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and me...
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Article
Open AccessEmerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
Endothelial–mesenchymal transition (EndoMT), a cellular differentiation process in which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells, has been observed not only durin...
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Article
Open AccessConstruction of transplantable artificial vascular tissue based on adipose tissue-derived mesenchymal stromal cells by a cell coating and cryopreservation technique
Prevascularized artificial three-dimensional (3D) tissues are effective biomaterials for regenerative medicine. We have previously established a scaffold-free 3D artificial vascular tissue from normal human de...
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Article
Open AccessIsolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare pulmonary disease characterised by the proliferation of smooth muscle-like cells (LAM cells), and an abundance of lymphatic vessels in LAM lesions. Studies reported tha...
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Article
Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors
Receptor endocytosis is crucial for integrating extracellular stimuli of pro-angiogenic factors, including vascular endothelial growth factor (VEGF), into the cell via signal transduction. VEGF not only trigge...
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Article
Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat
The in vivo mechanoresponsive and lubricating changes of the mandibular condylar cartilage (MCC) associated with mandibular lateral shift (MLS) and recovery are poorly understood. Using growing rats, we invest...
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Article
Open AccessInterleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma
Malignant melanoma is one of the untreatable cancers in which conventional therapeutic strategies, including chemotherapy, are hardly effective. Therefore, identification of novel therapeutic targets involved ...
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Article
Roles of TGF-β family signaling in stem cell renewal and differentiation
Transforming growth factor (TGF)-βs and their family members, including bone morphogenetic proteins (BMPs), Nodal and activins, have been implicated in the development and maintenance of various organs, in whi...
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Protocol
TGF-β Signaling in Embryonic Stem Cell-Derived Endothelial Cells
The roles of the transforming growth factor (TGF)-β superfamily in vasculogenesis have been implicated by the findings that mutations in genes encoding for various TGF-β superfamily signaling components exhibi...
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Article
BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells
Prostate cancer is one of the most common cancers in men. Several lines of evidence have suggested that bone morphogenetic protein (BMP) signals play important roles in the generation and progression of prosta...
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Chapter
Activin Signaling Pathways and Their Role in Xenopus Mesoderm Formation
Signals generated by members of the transforming growth factor-beta (TGF-β) superfamily mediate a diverse array of biological responses in immune function, growth control, cell differentiation, sexual reproductio...
