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Article
Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial
Staphylococcus aureus colonizes patients with atopic dermatitis (AD) and exacerbates disease by promoting inflammation. The present study investigated the safety and mechanisms of action of Staphylococcus hominis
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Article
Ultraviolet radiation damages self noncoding RNA and is detected by TLR3
Ultraviolet radiation induces an inflammatory response in the skin, but it remains unclear how cells in the skin detect this damage and trigger an inflammatory response. Richard L. Gallo and his colleagues rep...
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Article
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Gallo and his colleagues report that commensal bacteria on the skin help to dampen inflammation caused by skin injury in mice. They show that, after wounding, necrotic cells release RNA that triggers TLR3 on k...