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  1. No Access

    Article

    Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

    Staphylococcus aureus colonizes patients with atopic dermatitis (AD) and exacerbates disease by promoting inflammation. The present study investigated the safety and mechanisms of action of Staphylococcus hominis

    Teruaki Nakatsuji, Tissa R. Hata, Yun Tong, Joyce Y. Cheng, Faiza Shafiq… in Nature Medicine (2021)

  2. Article

    Open Access

    Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis

    Biofilm formation by bacterial pathogens is associated with numerous human diseases and can confer resistance to both antibiotics and host defenses. Many strains of Staphylococcus epidermidis are capable of formi...

    Kouki Nakamura, Alan M. O’Neill, Michael R. Williams, Laura Cau… in Scientific Reports (2020)

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  3. No Access

    Article

    HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

    Herpes simplex virus type 1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with c...

    Daniel T. MacLeod, Teruaki Nakatsuji, Kenshi Yamasaki… in Nature Communications (2013)

  4. No Access

    Article

    The microbiome extends to subepidermal compartments of normal skin

    Commensal microbes on the skin surface influence the behaviour of cells below the epidermis. We hypothesized that bacteria or their products exist below the surface epithelium and thus permit physical interact...

    Teruaki Nakatsuji, Hsin-I. Chiang, Shangi B. Jiang… in Nature Communications (2013)

  5. No Access

    Article

    Ultraviolet radiation damages self noncoding RNA and is detected by TLR3

    Ultraviolet radiation induces an inflammatory response in the skin, but it remains unclear how cells in the skin detect this damage and trigger an inflammatory response. Richard L. Gallo and his colleagues rep...

    Jamie J Bernard, Christopher Cowing-Zitron, Teruaki Nakatsuji… in Nature Medicine (2012)

  6. No Access

    Article

    Occurrence and distribution of capB in Antarctic microorganisms and study of its structure and regulation in the Antarctic biodegradative Pseudomonas sp. 30/3

    The analysis of the cold-shock domain (CSD)-encoding genes, capB and cspA, by PCR amplification showed presence of capB in all 18 Antarctic Pseudomonas isolates, but the absence of cspA. Nucleotide sequence analy...

    Gitika Panicker, Nazia Mojib, Teruaki Nakatsuji, Jackie Aislabie… in Extremophiles (2010)

  7. Article

    Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

    Gallo and his colleagues report that commensal bacteria on the skin help to dampen inflammation caused by skin injury in mice. They show that, after wounding, necrotic cells release RNA that triggers TLR3 on k...

    Yu** Lai, Anna Di Nardo, Teruaki Nakatsuji, Anke Leichtle, Yan Yang… in Nature Medicine (2009)

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