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Article
Open AccessObesity alters the mouse endometrial transcriptome in a cell context-dependent manner
Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are ...
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Article
Photoimmunology: how ultraviolet radiation affects the immune system
Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodula...
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Article
Open AccessIdentifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay
Obesity is associated with ~40% of cancer diagnoses but there are currently no effective preventive strategies, illustrating a need for chemoprevention. We previously demonstrated that fibroblast growth factor...
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Protocol
Lipectomizing Mice for Applications in Metabolism
The obesity epidemic is a critical public health problem closely associated with the development of metabolic disease. In obesity there is excess white adipose tissue, a dynamic tissue that has many biological...
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Chapter
Inhibition of UVB-Induced Nonmelanoma Skin Cancer: A Path from Tea to Caffeine to Exercise to Decreased Tissue Fat
Oral administration of green tea, black tea, or caffeine (but not the decaffeinated teas) inhibited ultraviolet B radiation (UVB)-induced skin carcinogenesis in SKH-1 mice. Studies with caffeine indicated that...
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Article
Ultraviolet radiation damages self noncoding RNA and is detected by TLR3
Ultraviolet radiation induces an inflammatory response in the skin, but it remains unclear how cells in the skin detect this damage and trigger an inflammatory response. Richard L. Gallo and his colleagues rep...
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Article
Protecting the boundary: the sentinel role of host defense peptides in the skin
The skin is our primary shield against microbial pathogens and has evolved innate and adaptive strategies to enhance immunity in response to injury or microbial insult. The study of antimicrobial peptide (AMP)...
