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  1. Article

    Open Access

    Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

    Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicate...

    Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger… in Leukemia (2022)

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  2. Article

    Open Access

    The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

    FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possib...

    Anne Charlet, Max Kappenstein, Philip Keye, Kathrin Kläsener, Cornelia Endres… in Leukemia (2022)

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  3. Article

    Open Access

    Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

    While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the exist...

    Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux… in Leukemia (2020)

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  4. No Access

    Article

    A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

    Targeted expression of transgenes is essential for the accurate representation of human disease in in vivo models. Current approaches to generate conditional transgenic mouse models are cumbersome and not amen...

    Khalid Shoumariyeh, Nicolas Schneider, Teresa Poggio, Pia Veratti… in Oncogene (2020)