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  1. Article

    Open Access

    Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

    The persistence of leukemic stem cells (LSCs) represents a problem in the therapy of chronic myeloid leukemia (CML). Hence, it is of utmost importance to explore the underlying mechanisms to develop new therap...

    Melanie Langhammer, Julia Schöpf, Timo Jaquet, Katharina Horn, Moritz Angel… in Leukemia (2023)

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  2. Article

    Open Access

    Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase

    The dimerization of RAF kinases represents a key event in their activation cycle and in RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key insights into this process defini...

    Lino Rohrer, Corinna Spohr, Carina Beha… in Cell Communication and Signaling (2023)

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  3. Article

    Open Access

    Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

    Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosi...

    Aladin Haimovici, Christoph Höfer, Mohamed Tarek Badr… in Cell Death & Disease (2022)

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  4. Article

    Open Access

    Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

    Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicate...

    Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger… in Leukemia (2022)

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  5. No Access

    Article

    Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

    Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoin...

    Florian Weinberg, Ricarda Griffin, Martina Fröhlich, Christoph Heining… in Oncogene (2020)

  6. No Access

    Article

    B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

    Copy number gains, point mutations and epigenetic silencing events are increasingly observed in genes encoding elements of the Ras/Raf/MEK/ERK signaling axis in human breast cancer. The three Raf kinases A-Raf...

    Martin Köhler, Sophia Ehrenfeld, Sebastian Halbach, Manuel Lauinger… in Oncogene (2019)