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  1. No Access

    Article

    ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer

    Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is treated with ALK tyrosine kinase inhibitors (TKIs), but the lack of activity of immune checkpoint inhibitors (ICIs) is poorly unde...

    Ines Mota, Enrico Patrucco, Cristina Mastini, Navin R. Mahadevan… in Nature Cancer (2023)

  2. Article

    Open Access

    Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo

    Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicate...

    Corinna Spohr, Teresa Poggio, Geoffroy Andrieux, Katharina Schönberger… in Leukemia (2022)

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  3. Article

    Open Access

    The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

    FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possib...

    Anne Charlet, Max Kappenstein, Philip Keye, Kathrin Kläsener, Cornelia Endres… in Leukemia (2022)

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  4. Article

    Open Access

    Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

    While cancer stem cells are well established in certain hematologic and solid malignancies, their existence in T cell lymphoma is unclear and the origin of disease is not fully understood. To examine the exist...

    Stefanie Kreutmair, Cathrin Klingeberg, Teresa Poggio, Geoffroy Andrieux… in Leukemia (2020)

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  5. No Access

    Article

    A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

    Targeted expression of transgenes is essential for the accurate representation of human disease in in vivo models. Current approaches to generate conditional transgenic mouse models are cumbersome and not amen...

    Khalid Shoumariyeh, Nicolas Schneider, Teresa Poggio, Pia Veratti… in Oncogene (2020)

  6. No Access

    Article

    Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

    In T lymphocytes, the Wiskott–Aldrich Syndrome protein (WASP) and WASP-interacting-protein (WIP) regulate T cell antigen receptor (TCR) signaling, but their role in lymphoma is largely unknown. Here we show th...

    Matteo Menotti, Chiara Ambrogio, Taek-Chin Cheong, Chiara Pighi… in Nature Medicine (2019)

  7. No Access

    Article

    Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

    PI3Kδ controls the expression of the recombinogenic enzyme AID; excessive AID activity caused by PI3Kδ inhibition can induce genomic instability in leukaemia and lymphoma cells, as well as in patients with chr...

    Mara Compagno, Qi Wang, Chiara Pighi, Taek-Chin Cheong, Fei-Long Meng… in Nature (2017)